Association of TMS-EEG interhemispheric imbalance with upper limb motor impairment in chronic stroke patients: An exploratory study.

OBJECTIVE

We aimed to investigate the involvement of interhemispheric cortical dynamics as measured by combined transcranial magnetic stimulation and electroencephalography (TMS-EEG) in recovery of upper limb (UL) motor functions in chronic stroke patients.

METHODS

Ten patients with a history of single ischemic chronic stroke were enrolled (4F, 63.8 ± 9.9 years). Each patient underwent TMS-EEG recordings to evaluate interhemispheric cortical dynamics as well as a reaching task recorded with inertial measurement units, and a series of clinical assessments. TMS-EEG neurophysiological data were analysed considering spatiotemporal, power response, and interhemispheric balance (IHB) dynamics.

RESULTS

We found that IHB index (IHBi) and low-frequency power (LFP) (4-13 Hz) in the affected hemisphere were associated with the degree of UL impairment.

CONCLUSION

Increased IHBi due to stroke is an unfavourable factor of UL' functions. Similarly, LFP of both hemispheres is strongly correlated with clinical and kinematic outcomes.

SIGNIFICANCE: TMS-EEG biomarkers of interhemispheric unbalance could be used to estimate functional recovery and drive tailored neuromodulation and neurorehabilitation approaches.