Association of atropine use during neonatal intubation with cardiac arrest, severe bradycardia, and other adverse events: a report from NEAR4NEOS.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Sawyer Taylor, Narvey Michael, Tyler Michelle D, Abou Mehrem Ayman, Iben Sabine, DeMartino Cassandra, Tingay David, Hodgson Kate, Kim Jae, Herrick Heidi, Unrau Jennifer, Puia-Dumitrescu Mihai, Shay Rebecca, DeMeo Stephen, Assaad Michael-Andrew, O'Shea Joyce, Brajkovic Ivana, Quek Bin Huey, Glass Kristen, Wagner Michael, Bibl Katharina, Rumpel Jennifer, McKissic Devin, Pouppirt Nicole, Wildenhain Paul, Napolitano Natalie, Shults Justine, Reiter Joseph, Foglia Elizabeth E, Nishisaki Akira, National Emergency Airway Registry for Neonates (NEAR4NEOS) investigators
Аннотация
STUDY DESIGN: Retrospective multicenter cohort study of neonatal TIs in the NEAR4NEOS registry (2014-2023). Multivariable logistic regression assessed associations between atropine use and cardiac arrest (primary outcome), along with safety and procedural outcomes, adjusting for confounders.
RESULTS: Atropine was used in 8189 of 13,085 TIs (62.6%). It was not associated with reduced odds of cardiac arrest (aOR 0.52, 95% CI 0.25-1.09). Atropine use was associated with lower odds of severe bradycardia (aOR 0.33, 95% CI 0.26-0.41), but higher odds of oxygen desaturation (aOR 1.35, 95% CI 1.22-1.49) and lower first-attempt success (aOR 0.76, 95% CI 0.69-0.85).
CONCLUSION: Atropine use during neonatal TI was not associated with reduced cardiac arrest. Although it reduced severe bradycardia, it was associated with increased desaturation and lower first-attempt success, warranting further study.