Frontiers in neuroscience · 2026
The impact of an app-delivered mindfulness-based intervention on resting-state functional connectivity in pediatric concussion: a pilot study.
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Brown Olivier, Smith Andra, Cairncross Molly, Dodd Andrew B, Goldfield Gary S, Gray Clare, Harris Ashley D, Jaworska Natalia, Saab Bechara J, Sicard Veronik, Silverberg Noah D, Walker Lisa A S, Zemek Roger, Ledoux Andrée-Anne
Аннотация
RATIONALE: Concussion disrupts brain connectivity, and effective treatments remain limited. Mindfulness-based interventions (MBIs) may influence functional connectivity (FC) of networks affected by concussion, but pediatric trials are lacking. This study investigated whether an app-delivered MBI produced greater FC changes than a sham condition across the default mode (DMN), salience (SN), and central executive (CEN) networks.
METHODS: This randomized clinical trial (NCT05105802) recruited participants aged 12.00-17.99 years from the emergency department or interdisciplinary concussion clinic, then randomly assigned them to MBI or cognitive sham. Brain imaging sessions occurred at 72 h and 4 weeks post-concussion. Region-of-interest and seed-to-voxel analyses examined Group × Time interactions in FC across DMN, SN, and CEN (p < 0.050 FDR ).
RESULTS: Thirty-six participants were included (MBI: n = 16, median [IQR] age = 14.23 [13.52-15.65] years, 31% female; Sham: n = 20, median [IQR] age = 14.05 [13.13-16.26] years, 45% female). Intention-to-treat analyses revealed significant Group × Time interactions across networks. DMN-CEN FC patterns differed, with MBI participants showing diminished FC. Within DMN, four clusters showed significant interactions (p < 0.050 FDR ), three exhibiting larger FC reductions at 4 weeks in MBI participants. MBI participants showed greater FC increase in one SN cluster (p = 0.040 FDR ) and larger FC decrease in one CEN cluster (p = 0.024 FDR ) at 4 weeks. Per-protocol analyses identified one significant DMN cluster (p < 0.001 FDR ) where MBI participants exhibited greater FC increases.
CONCLUSION: Mindfulness-based intervention training led to changes in FC in networks implicated in concussion recovery. Larger studies are needed to support these findings.
CLINICAL TRIAL REGISTRATION: https://clinicaltrials.gov/study/NCT05105802, identifier NCT05105802.
METHODS: This randomized clinical trial (NCT05105802) recruited participants aged 12.00-17.99 years from the emergency department or interdisciplinary concussion clinic, then randomly assigned them to MBI or cognitive sham. Brain imaging sessions occurred at 72 h and 4 weeks post-concussion. Region-of-interest and seed-to-voxel analyses examined Group × Time interactions in FC across DMN, SN, and CEN (p < 0.050 FDR ).
RESULTS: Thirty-six participants were included (MBI: n = 16, median [IQR] age = 14.23 [13.52-15.65] years, 31% female; Sham: n = 20, median [IQR] age = 14.05 [13.13-16.26] years, 45% female). Intention-to-treat analyses revealed significant Group × Time interactions across networks. DMN-CEN FC patterns differed, with MBI participants showing diminished FC. Within DMN, four clusters showed significant interactions (p < 0.050 FDR ), three exhibiting larger FC reductions at 4 weeks in MBI participants. MBI participants showed greater FC increase in one SN cluster (p = 0.040 FDR ) and larger FC decrease in one CEN cluster (p = 0.024 FDR ) at 4 weeks. Per-protocol analyses identified one significant DMN cluster (p < 0.001 FDR ) where MBI participants exhibited greater FC increases.
CONCLUSION: Mindfulness-based intervention training led to changes in FC in networks implicated in concussion recovery. Larger studies are needed to support these findings.
CLINICAL TRIAL REGISTRATION: https://clinicaltrials.gov/study/NCT05105802, identifier NCT05105802.