Monitoring of Nonsurgical Treatment of Peri-Implantitis Traditional Measurement Methods and aMMP-8 Test Technology: A Pilot Study.

INTRODUCTION

This pilot study investigated the effects of ≥6 weeks after nonsurgical treatment of the tissues surrounding dental implants, using clinical traditional methods and the aMMP-8 test technology in 39 patients.

METHODS AND MATERIALS: In the peri-implant pocket of 39 dental implants, an aMMP-8 concentration, gingival bleeding (BOP), and implant pocket depth (PPD), and an x-ray for radiologic bone level (RBL) were taken. The ≥6 weeks after nonsurgical treatment of the implants was carried out, and the treatment response was evaluated again after 30 days using the same methods.

RESULTS

The ≥6 weeks after nonsurgical treatment achieved a decrease in the aMMP-8 enzyme level, BOP, and the implant pockets. After 1 month, no statistically significant positive changes were observed in the result of the BOP (p=0.02) or the depth of deepened implant pockets (p=0.02) without the effect of surgical treatment, but there was a statistically significant reduction in the levels of the aMMP-8 chair-side test (p=0.001).

CONCLUSIONS

Signs of inflammation were found to be very common in the tissues surrounding the implant. Getting the peri-implant tissue healthy in ≥6 weeks after nonsurgical treatment with traditional nonsurgical treatment would seem to be surprisingly challenging. The applicability of the aMMP-8 enzyme test in diagnosing and reading the real-time health status of the surrounding tissues in monitoring ≥6 weeks after nonsurgical treatments provides a useful and accurate method to control the health and disease. Trial Registration: ClinicalTrials.gov Identifier: NCT06408467.