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DOI 10.1016/j.ijid.2021.10.048

Медицинская библиотека · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021

Post-acute COVID-19 syndrome after reinfection and vaccine breakthrough by the SARS-CoV-2 Gamma variant in Brazil.

Penetra Stephanie L S, da Silva Michele F B, Resende Paola, Pina-Costa Anielle, Santos Heloisa F P, Guaraldo Lusiele, Calvet Guilherme A, Ogrzewalska Maria, Arantes Ighor, Zukeram Ketiuce, de Araújo Mia F, Lima Ana Beatriz Machado, Lopes Renata Serrano, Lira-Silva Larissa R, Moraes Isabella V, Wakimoto Mayumi D, Fuller Trevon L, Gabaglia Claudia Raja, Espíndola Otávio M, Bonaldo Myrna C, Daniel-Ribeiro Cláudio Tadeu, Whitworth Jimmy, Smith Chris, Nielsen-Saines Karin, Pauvolid-Correa Alex, Siqueira Marilda M, Brasil Patricia

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Аннотация

We describe a case of prolonged COVID-19 caused by the SARS-CoV-2 Gamma variant in a fully vaccinated healthcare worker, 387 days after an infection caused by lineage B.1.1.33. Infections were confirmed by whole-genome sequencing and corroborated by the detection of neutralizing antibodies in convalescent serum samples. Considering the permanent exposure of this healthcare worker to SARS-CoV-2, the waning immunity after the first infection, the low efficacy of the inactivated vaccine at preventing COVID-19, the immune escape of the Gamma variant (VOC), and the burden of post-COVID syndrome, this individual would have benefited from an additional dose of a heterologous vaccine.

Для цитирования: Penetra Stephanie L S, da Silva Michele F B, Resende Paola, Pina-Costa Anielle, Santos Heloisa F P, Guaraldo Lusiele, Calvet Guilherme A, Ogrzewalska Maria, Arantes Ighor, Zukeram Ketiuce, de Araújo Mia F, Lima Ana Beatriz Machado, Lopes Renata Serrano, Lira-Silva Larissa R, Moraes Isabella V, Wakimoto Mayumi D, Fuller Trevon L, Gabaglia Claudia Raja, Espíndola Otávio M, Bonaldo Myrna C, Daniel-Ribeiro Cláudio Tadeu, Whitworth Jimmy, Smith Chris, Nielsen-Saines Karin, Pauvolid-Correa Alex, Siqueira Marilda M, Brasil Patricia. Post-acute COVID-19 syndrome after reinfection and vaccine breakthrough by the SARS-CoV-2 Gamma variant in Brazil.. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. 2021. DOI: 10.1016/j.ijid.2021.10.048.

Предметные рубрики MeSH

BrazilCOVID-19HumansImmunization, PassiveReinfectionSARS-CoV-2Vaccines, InactivatedCOVID-19 SerotherapyPost-Acute COVID-19 Syndrome
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