MedElevator
Войти в исследования The journal of allergy and clinical immunology. In practice · 2026
Heart Rate Variability Patterns Differentiate Between Positive and Negative Oral Food Challenges in Children With Food Allergy.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Epstein-Rigbi Na'ama, Koren Yael, Toledano Limor Ben-Nun, Blauground Rotem, Elkan Matan, Nachshon Liat, Elizur Arnon, Noham Itamar
Аннотация
BACKGROUND: Subjective complaints as well as mild symptoms during oral food challenges (OFCs) present a clinical dilemma and may result in false-positive OFCs.
OBJECTIVE: To examine whether heart rate variability (HRV) patterns can help differentiate between patients with and without an objective allergic reaction during an OFC.
METHODS: In this comparative cohort study, we examined the HRV patterns of children undergoing OFCs using a smart wristband device that continuously measured heart rate values. Comparison between cohorts was performed retrospectively using the derivative modified cardiac sympathetic index (CSI).
RESULTS: Data from 104 pediatric patients were analyzed. Of these, 57 had a positive OFC (developed an allergic reaction), whereas 47 had a negative OFC. The baseline modified CSI scores (pre-OFC) were comparable between patients from both cohorts (P = .48). The HRV patterns throughout the OFCs were significantly different between positive and negative challenges (P < .001). Patients with subjective complaints who had a negative OFC had a significantly lower modified CSI compared with patients with a positive challenge (P = .005). The scores of positive OFCs were not affected by reaction severity as measured by the Sampson score (Sampson score 2 vs Sampson scores 3 and 4) (P = .93). When comparing patients with a perioral rash with a positive versus a negative OFC, there were significantly higher scores in the positive OFC cohort (P < .001).
CONCLUSIONS: HRV patterns differentiate between positive and negative OFCs, regardless of the presence of subjective complaints. With further investigation, HRV monitoring may have the potential to serve as an objective adjunctive tool.
OBJECTIVE: To examine whether heart rate variability (HRV) patterns can help differentiate between patients with and without an objective allergic reaction during an OFC.
METHODS: In this comparative cohort study, we examined the HRV patterns of children undergoing OFCs using a smart wristband device that continuously measured heart rate values. Comparison between cohorts was performed retrospectively using the derivative modified cardiac sympathetic index (CSI).
RESULTS: Data from 104 pediatric patients were analyzed. Of these, 57 had a positive OFC (developed an allergic reaction), whereas 47 had a negative OFC. The baseline modified CSI scores (pre-OFC) were comparable between patients from both cohorts (P = .48). The HRV patterns throughout the OFCs were significantly different between positive and negative challenges (P < .001). Patients with subjective complaints who had a negative OFC had a significantly lower modified CSI compared with patients with a positive challenge (P = .005). The scores of positive OFCs were not affected by reaction severity as measured by the Sampson score (Sampson score 2 vs Sampson scores 3 and 4) (P = .93). When comparing patients with a perioral rash with a positive versus a negative OFC, there were significantly higher scores in the positive OFC cohort (P < .001).
CONCLUSIONS: HRV patterns differentiate between positive and negative OFCs, regardless of the presence of subjective complaints. With further investigation, HRV monitoring may have the potential to serve as an objective adjunctive tool.