Transcatheter Tricuspid Valve Replacement in Patients With Cardiac Implantable Electronic Device Leads: The TRIPLACE Registry.
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Traynor Bryan P, Scotti Andrea, Puri Rishi, Sturla Matteo, Zahr Firas, Boone Robert, Kodali Susheel, Tchétché Didier, De Backer Ole, Coisne Augustin, Ludwig Sebastian, Stolz Lukas, Loureiro Rodrigo Estévez, Adam Matti, De Marco Federico, Biroli Matteo, Ho Edwin C, Cheung Anson, Patrascu Alexandru, Alnasser Sami, Chadderdon Scott, Lulic Davorka, Bartkowiak Joanna, Echarte-Morales Julio, Sievert Horst, Byrne Timothy, Maisano Francesco, Frerker Christian, Dumonteil Nicolas, Oliva Omar A, Rudolph Tanja K, Rudolph Felix, Krishnaswamy Amar, Kapadia Samir R, Portillo Juan Del, Rodés-Cabau Josep, Schofer Niklas, Granada Juan F, Hausleiter Jörg, Hahn Rebecca T, Modine Thomas, Latib Azeem, Fam Neil
Аннотация
OBJECTIVES: This study sought to investigate the clinical, procedural, and lead-related outcomes of orthotopic TTVR in patients with transvalvular CIED leads.
METHODS: All consecutive patients enrolled in the multicenter TRIPLACE (Global Multicenter Registry on Transcatheter Tricuspid Valve Replacement) registry were included for analysis. Patients were stratified based on the presence of a CIED lead traversing the tricuspid valve. Changes in lead function parameters were assessed after TTVR in a subset of these patients who had pacemaker lead parameter data recorded. Lead failure was defined as structural or electrical malfunction requiring new lead or CIED insertion.
RESULTS: Among 395 patients, 104 (26.3%) had transvalvular CIED leads. Procedural success, symptomatic improvement, and 30-day mortality were comparable between those with and without CIED. Patients with CIED leads had lower rates of mild or less residual tricuspid regurgitation (82.6% vs 91.4%; P < 0.041) and higher rates of moderate or greater paravalvular leak (17.1% vs 7.1%; P < 0.017). Lead failure occurred in 5.8% over a median follow-up time of 183 days, with modest changes in pacing thresholds. No significant increase in adverse events or mortality was observed at 30 days.
CONCLUSIONS: Orthotopic TTVR in patients with transvalvular CIED leads can be safely and effectively performed with low rates of lead failure. Significant paravalvular leak and residual tricuspid regurgitation is more common with a jailed lead. These patients require close CIED follow-up with alternative pacing strategies in place, particularly when pacing dependent. (Global Multicenter Registry on Transcatheter TRIcuspid Valve RePLACEment [TRIPLACE]; NCT06033274).