Unilateral diffuse adrenal hyperplasia masquerading as aldosterone-producing adenoma in primary hyperaldosteronism.

We report a case of primary hyperaldosteronism due to unilateral diffuse hyperplasia. Unilateral adrenalectomy resulted in an improvement of hypertension and hyperaldosteronism. Six months after surgery, the plasma aldosterone level and plasma renin activity remained normal, but blood pressure returned to an abnormally high level. We have reviewed the literature and discuss the pathogenesis of this disorder.