PloS one · 2018
Ilheus and Saint Louis encephalitis viruses elicit cross-protection against a lethal Rocio virus challenge in mice.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Amarilla Alberto Anastacio, Fumagalli Marcilio Jorge, Figueiredo Mario Luis, Lima-Junior Djalma S, Santos-Junior Nilton Nascimento, Alfonso Helda Liz, Lippi Veronica, Trabuco Amanda Cristina, Lauretti Flavio, Muller Vanessa Danielle, Colón David F, Luiz João P M, Suhrbier Andreas, Setoh Yin Xiang, Khromykh Alexander A, Figueiredo Luiz Tadeu Moraes, Aquino Victor Hugo
Аннотация
Rocio virus (ROCV) was the causative agent of an unprecedented outbreak of encephalitis during the 1970s in the Vale do Ribeira, Sao Paulo State, in the Southeast region of Brazil. Surprisingly, no further cases of ROCV infection were identified after this outbreak; however, serological surveys have suggested the circulation of ROCV among humans and animals in different regions of Brazil. Cross-protective immunity among flaviviruses is well documented; consequently, immunity induced by infections with other flaviviruses endemic to Brazil could potentially be responsible for the lack of ROCV infections. Herein, we evaluated the cross-protection mediated by other flaviviruses against ROCV infection using an experimental C57BL/6 mouse model. Cross-protection against ROCV infection was observed when animals had prior exposure to Ilheus virus or Saint Louis encephalitis virus, suggesting that cross-reactive anti-flavivirus antibodies may limit ROCV disease outbreaks.