PloS one · 2015
HIV-1/HAART-Related Lipodystrophy Syndrome (HALS) Is Associated with Decreased Circulating sTWEAK Levels.
СтатьяМногоцентровое исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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López-Dupla Miguel, Maymó-Masip Elsa, Martínez Esteban, Domingo Pere, Leal Manuel, Peraire Joaquim, Viladés Consuelo, Veloso Sergi, Arnedo Mireia, Ferrando-Martínez Sara, Beltrán-Debón Raúl, Alba Verónica, Gatell Josep Ma, Vendrell Joan, Vidal Francesc, Chacón Matilde R
Аннотация
BACKGROUND AND OBJECTIVES: Obesity and HIV-1/HAART-associated lipodystrophy syndrome (HALS) share clinical, pathological and mechanistic features. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a multifunctional cytokine that plays an important role in obesity and related diseases. We sought to explore the relationship between HALS and circulating levels of soluble (s) TWEAK and its scavenger receptor sCD163.
METHODS: This was a cross-sectional multicenter study of 120 HIV-1-infected patients treated with a stable HAART regimen; 56 with overt HALS and 64 without HALS. Epidemiological and clinical variables were determined. Serum levels of sTWEAK and sCD163 levels were measured by ELISA. Results were analyzed with Student's t-test, Mann-Whitney U and χ2 test. Pearson and Spearman correlation were used to estimate the strength of association between variables.
RESULTS: Circulating sTWEAK was significantly decreased in HALS patients compared with non-HALS patients (2.81±0.2 vs. 2.94±0.28 pg/mL, p = 0.018). No changes were observed in sCD163 levels in the studied cohorts. On multivariate analysis, a lower log sTWEAK concentration was independently associated with the presence of HALS (OR 0.027, 95% CI 0.001-0.521, p = 0.027).
CONCLUSIONS: HALS is associated with decreased sTWEAK levels.
METHODS: This was a cross-sectional multicenter study of 120 HIV-1-infected patients treated with a stable HAART regimen; 56 with overt HALS and 64 without HALS. Epidemiological and clinical variables were determined. Serum levels of sTWEAK and sCD163 levels were measured by ELISA. Results were analyzed with Student's t-test, Mann-Whitney U and χ2 test. Pearson and Spearman correlation were used to estimate the strength of association between variables.
RESULTS: Circulating sTWEAK was significantly decreased in HALS patients compared with non-HALS patients (2.81±0.2 vs. 2.94±0.28 pg/mL, p = 0.018). No changes were observed in sCD163 levels in the studied cohorts. On multivariate analysis, a lower log sTWEAK concentration was independently associated with the presence of HALS (OR 0.027, 95% CI 0.001-0.521, p = 0.027).
CONCLUSIONS: HALS is associated with decreased sTWEAK levels.
Предметные рубрики MeSH
AdultAnti-HIV AgentsAntigens, CDAntigens, Differentiation, MyelomonocyticAntiretroviral Therapy, Highly ActiveCross-Sectional StudiesCytokine TWEAKFemaleGene ExpressionHIV-1HIV-Associated Lipodystrophy SyndromeHumansMaleMiddle AgedMultivariate AnalysisReceptors, Cell SurfaceTumor Necrosis FactorsCD163 Antigen