Journal of acquired immune deficiency syndromes (1999) · 2013
Prevalence of HIV-1 dual infection in long-term nonprogressor-elite controllers.
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Pernas María, Casado Concepción, Sandonis Virginia, Arcones Carolina, Rodríguez Carmen, Ruiz-Mateos Ezequiel, Ramírez de Arellano Eva, Rallón Norma, Del Val Margarita, Grau Eulalia, López-Vazquez Mariola, Leal Manuel, Del Romero Jorge, López Galíndez Cecilio
Аннотация
INTRODUCTION: Human immunodeficiency virus type 1 (HIV-1) dual infection (DI) in long-term nonprogressor-elite controller patients (LTNP-EC) has been described only in sporadic cases and then, consequences in disease progression are not clearly established. To fill-up this limited knowledge, we analyzed, for the first time, the prevalence, host genetic polymorphisms, and clinical consequences of HIV-1 DI in a group of LTNP-EC.
METHODS: For DI detection, nucleotide sequences in env gene from viruses from 20 LTNP-EC were analyzed by maximum likelihood. Epidemiological and clinical parameters and host factors of patients were also studied.
RESULTS: DI was detected in 4 (20%) of the 20 LTNP-EC, of which 3 maintained the elite controller status. CD4⁺ T-cell counts were not different between single and DI patients although higher CD8⁺ T-cell counts were observed in DI patients, and, consequently, the CD4⁺/CD8⁺ ratios were lower in LTNP-EC DI patients.
CONCLUSIONS: Prevalence of HIV-1 DIs in LTNP-EC is similar to other groups of HIV-1 patients; in addition, DI was not associated with loss of disease control in the patients. These DI LTNP-EC patients showed, in comparison with single infected patients, higher numbers of CD8⁺ T cells and lower CD4⁺/CD8⁺ ratios.
METHODS: For DI detection, nucleotide sequences in env gene from viruses from 20 LTNP-EC were analyzed by maximum likelihood. Epidemiological and clinical parameters and host factors of patients were also studied.
RESULTS: DI was detected in 4 (20%) of the 20 LTNP-EC, of which 3 maintained the elite controller status. CD4⁺ T-cell counts were not different between single and DI patients although higher CD8⁺ T-cell counts were observed in DI patients, and, consequently, the CD4⁺/CD8⁺ ratios were lower in LTNP-EC DI patients.
CONCLUSIONS: Prevalence of HIV-1 DIs in LTNP-EC is similar to other groups of HIV-1 patients; in addition, DI was not associated with loss of disease control in the patients. These DI LTNP-EC patients showed, in comparison with single infected patients, higher numbers of CD8⁺ T cells and lower CD4⁺/CD8⁺ ratios.
Предметные рубрики MeSH
AdultBase SequenceCD4 Lymphocyte CountCD4-CD8 RatioCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCoinfectionDisease ProgressionFemaleFollow-Up StudiesHIV Long-Term SurvivorsHIV-1HLA-B AntigensHumansImmunity, InnateMaleMiddle AgedPhylogenyPrevalenceSpainViral LoadVirus Replicationenv Gene Products, Human Immunodeficiency Virus