Antioxidants (Basel, Switzerland) · 2026
Selenium Status Is Associated with Inflammation in Epicardial Adipose Tissue in Elderly Patients with Coronary Artery Disease.
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Opstad Trine Baur, Opdahl Fredrik Lossius, Larsen Steen, Åkra Sissel, Palmero Sheryl, Tønnessen Theis, Solheim Svein, Alexander Jan, Alehagen Urban, Lunde Ida Gjervold
Аннотация
BACKGROUND: Inflammation in epicardial adipose tissue (EAT) contributes to cardiovascular disease through the local production of pro-inflammatory cytokines affecting the adjacent myocardium. Selenium (Se) is essential for selenoprotein-mediated antioxidant and anti-inflammatory functions. We investigated associations between Se status and inflammatory markers in EAT and in the circulation in patients with coronary artery disease (CAD).
METHODS: Patients with CAD undergoing coronary artery bypass grafting (n = 52) and valve disease patients receiving valve replacement serving as controls (n = 22) were included from the ATICH study. EAT biopsies were obtained during open-chest chest surgery. Serum Se was measured by inductively coupled plasma mass spectrometry. Associations between Se and EAT mRNA expression of Nod-like receptor family pyrin domain-containing protein 3 (NLRP3) inflammasome components and cytokines, as well as circulating inflammatory markers, were assessed using Spearman's rho and group comparisons based on median Se levels.
RESULTS: Se concentrations were lower in CAD patients than controls (0.9 vs. 1.1 µmol/L, p = 0.025). In CAD patients, Se levels correlated with EAT expression of CASP1 and IL18, and with circulating IL-6. Se levels above the median were associated with lower EAT expression of CASP1 and NLRP3 and reduced IL-6 levels (p < 0.05, all). Our analysis of publicly available RNA seq data demonstrated selenoprotein's presence in EAT.
CONCLUSION: Lower Se status in CAD was associated with increased systemic and EAT inflammation, suggesting a role for selenoprotein-dependent antioxidant mechanisms in regulating cardiac adipose tissue inflammation.
METHODS: Patients with CAD undergoing coronary artery bypass grafting (n = 52) and valve disease patients receiving valve replacement serving as controls (n = 22) were included from the ATICH study. EAT biopsies were obtained during open-chest chest surgery. Serum Se was measured by inductively coupled plasma mass spectrometry. Associations between Se and EAT mRNA expression of Nod-like receptor family pyrin domain-containing protein 3 (NLRP3) inflammasome components and cytokines, as well as circulating inflammatory markers, were assessed using Spearman's rho and group comparisons based on median Se levels.
RESULTS: Se concentrations were lower in CAD patients than controls (0.9 vs. 1.1 µmol/L, p = 0.025). In CAD patients, Se levels correlated with EAT expression of CASP1 and IL18, and with circulating IL-6. Se levels above the median were associated with lower EAT expression of CASP1 and NLRP3 and reduced IL-6 levels (p < 0.05, all). Our analysis of publicly available RNA seq data demonstrated selenoprotein's presence in EAT.
CONCLUSION: Lower Se status in CAD was associated with increased systemic and EAT inflammation, suggesting a role for selenoprotein-dependent antioxidant mechanisms in regulating cardiac adipose tissue inflammation.