Acta paediatrica (Oslo, Norway : 1992) · 2009
Genetic polymorphisms in Thai neonates with hyperbilirubinemia.
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Prachukthum Sariya, Nunnarumit Pracha, Pienvichit Paneeya, Chuansumrit Ampaiwan, Songdej Daunthida, Kajanachumpol Saowanee, Pakakasama Samart, Hongeng Suradej
Аннотация
AIM: Polymorphisms of the UGT1A1 gene, SLCO1B1 gene and GST gene have been associated with significant hyperbilirubinemia. We would like to determine whether the variation of UGT1A1 gene, SLCO1B1 gene and GST gene may play a significant role in neonatal hyperbilirubinemia in Thai infants.
METHODS: Ninety-one study subjects (hyperbilirubinemic group) and 86 control subjects were studied.
RESULTS: The cause of neonatal hyperbilirubinemia could not be identified in 64 infants (70.3%), ABO blood group incompatibility in 14.3% and Glucose-6-phosphate dehydrogenase (G-6-PD) deficiency in 8.8%. In the hyperbilirubinemic group, 23 of 91 (25.3%) infants demonstrated variant of UGT1A1 at nucleotides (nt) 211 as compared to 6 of 86 (7%) in the control group (p = 0.001). There were no significant differences between groups in the variants UGT1A1 at nt 686, SLCO1B1 gene at nt 388, 463 and the GST gene. Male infants with G-6-PD deficiency were associated with hyperbilirubinemia (21.2% vs. 4.8% in the control group) with an odds ratio (OR) of 5.37 (p = 0.02). The relationship between G-6-PD and variant in UGT1A1 gene at nt 211 could not be determined.
CONCLUSION: Thai infants with variant in the UGT1A1 at nt 211 or with G-6-PD deficiency are at higher risk for developing neonatal hyperbilirubinemia.
METHODS: Ninety-one study subjects (hyperbilirubinemic group) and 86 control subjects were studied.
RESULTS: The cause of neonatal hyperbilirubinemia could not be identified in 64 infants (70.3%), ABO blood group incompatibility in 14.3% and Glucose-6-phosphate dehydrogenase (G-6-PD) deficiency in 8.8%. In the hyperbilirubinemic group, 23 of 91 (25.3%) infants demonstrated variant of UGT1A1 at nucleotides (nt) 211 as compared to 6 of 86 (7%) in the control group (p = 0.001). There were no significant differences between groups in the variants UGT1A1 at nt 686, SLCO1B1 gene at nt 388, 463 and the GST gene. Male infants with G-6-PD deficiency were associated with hyperbilirubinemia (21.2% vs. 4.8% in the control group) with an odds ratio (OR) of 5.37 (p = 0.02). The relationship between G-6-PD and variant in UGT1A1 gene at nt 211 could not be determined.
CONCLUSION: Thai infants with variant in the UGT1A1 at nt 211 or with G-6-PD deficiency are at higher risk for developing neonatal hyperbilirubinemia.
Предметные рубрики MeSH
Analysis of VarianceBilirubinCase-Control StudiesChi-Square DistributionDNADNA Mutational AnalysisFemaleGlucosephosphate Dehydrogenase DeficiencyGlucuronosyltransferaseGlutathione TransferaseHumansHyperbilirubinemia, NeonatalInfant, NewbornLiver-Specific Organic Anion Transporter 1MaleOrganic Anion TransportersPolymorphism, GeneticRegression AnalysisRisk FactorsThailandUGT1A1 Enzyme