Annales de medecine interne · 2001
[Autoimmune peripheral neuropathies with anti-MAG antibodies and hematological disorders. Five cases].
Клинический случайАннотация на английскомСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Andrès E, Vinzio S, Maloisel F, Carre S, Perrin A E, Goichot B, Schlienger J L
Аннотация
OBJECTIVE: The aim of this study was to report our experience with autoimmune neuropathies associated with hematological disorders and to describe their etiological and clinical polymorphism.
PATIENTS AND METHODS: A retrospective study was conducted in five patients with autoimmune peripheral neuropathies with anti-MAG (myelin-associated glycoprotein) antibodies.
RESULTS: Autoimmune neuropathies were associated with Waldenström's macroglobulinemia (n=2), Hodgkin disease (n=1), chronic lymphocytic leukemia (n=1) and idiopathic polyclonal B lymphoproliferation (n=1). Most of the patients had a sensorial polyneuropathy, predominant in the legs, exhibiting slow progress. Our patients showed a disappointing response to chemotherapy with stabilization or short response.
PATIENTS AND METHODS: A retrospective study was conducted in five patients with autoimmune peripheral neuropathies with anti-MAG (myelin-associated glycoprotein) antibodies.
RESULTS: Autoimmune neuropathies were associated with Waldenström's macroglobulinemia (n=2), Hodgkin disease (n=1), chronic lymphocytic leukemia (n=1) and idiopathic polyclonal B lymphoproliferation (n=1). Most of the patients had a sensorial polyneuropathy, predominant in the legs, exhibiting slow progress. Our patients showed a disappointing response to chemotherapy with stabilization or short response.
Предметные рубрики MeSH
AdultAgedAged, 80 and overAntibodies, Anti-IdiotypicAutoimmune DiseasesDisease ProgressionFemaleHematologic DiseasesHodgkin DiseaseHumansLeukemia, Lymphocytic, Chronic, B-CellLymphoproliferative DisordersMaleMiddle AgedMyelin-Associated GlycoproteinPolyneuropathiesRetrospective StudiesTreatment OutcomeWaldenstrom Macroglobulinemia