[Hyperlipidemia, blood coagulation factors, hereditary familial factors and coronary atherosclerosis].

The identification of risk factors is very important for primary and secondary prevention of coronary artery disease. Among the different risk factors, the individual predisposition plays an important role. We have studied 130 patients with old myocardial infarction (Group A), 38 subjects belonging to the same family (Group B) and 147 control subjects in order to investigate: familiarity of coronary artery disease; distribution of lipids, lipoproteins and fibrinogen; distribution of these parameters in subjects with and without familiarity for coronary artery disease. Familiar forms showed similar lipemic and coagulative profiles as occasional forms. However, groups A and B showed significant variations in HDL-cholesterol, apolipoprotein A1, Apo A1/B ratio and in fibrinogen when compared with control subjects. These results confirm the important role of these factors and their genetical distribution. The importance of familiar distribution is also evident.