Hearing research · 2025
Central functional connectivity reorganization in idiopathic tinnitus.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Shen Xingqian, Wang Linlin, Li Jing, Liu Yingzhao, Pan Hui, Zhou Ziqi, Fan Wenliang, Xiao Hongjun, Liu Bo
Аннотация
PURPOSE: To explore functional connectivity alterations in idiopathic tinnitus patients at the integrity, network, and edge levels through resting-state functional magnetic resonance imaging (rs-fMRI), and elucidating central plasticity changes in idiopathic tinnitus from the perspective of central functional connectivity patterns.
METHOD: Collect rs-fMRI data from 74 patients with idiopathic tinnitus and 98 healthy volunteers, analyze the functional connectivity differences between the two groups at the integrity, network, and edge levels, and explore the correlation between these differences and the clinical characteristics of idiopathic tinnitus patients.
RESULT: Patients with idiopathic tinnitus significantly reduce node degree in the left parahippocampal gyrus, left amygdala, and bilateral Heschl gyrus. At the network level, the intranetwork functional connectivity strength in the auditory network (AUN) of idiopathic tinnitus patients is significantly reduced, and the internetwork connectivity strength between the auditory network (AUN) and the ventral attention network (VAN) is significantly reduced. In addition, we found that the functional connectivity strength of two pairs of regions of interest (ROI) increased dramatically at the edge level, while the functional connectivity strength of nine pairs of ROI significantly decreased.
CONCLUSION: Central functional connectivity reorganization in idiopathic tinnitus patients involves not only the auditory cortex but also the limbic system and cortical regions responsible for attention shifting.
METHOD: Collect rs-fMRI data from 74 patients with idiopathic tinnitus and 98 healthy volunteers, analyze the functional connectivity differences between the two groups at the integrity, network, and edge levels, and explore the correlation between these differences and the clinical characteristics of idiopathic tinnitus patients.
RESULT: Patients with idiopathic tinnitus significantly reduce node degree in the left parahippocampal gyrus, left amygdala, and bilateral Heschl gyrus. At the network level, the intranetwork functional connectivity strength in the auditory network (AUN) of idiopathic tinnitus patients is significantly reduced, and the internetwork connectivity strength between the auditory network (AUN) and the ventral attention network (VAN) is significantly reduced. In addition, we found that the functional connectivity strength of two pairs of regions of interest (ROI) increased dramatically at the edge level, while the functional connectivity strength of nine pairs of ROI significantly decreased.
CONCLUSION: Central functional connectivity reorganization in idiopathic tinnitus patients involves not only the auditory cortex but also the limbic system and cortical regions responsible for attention shifting.