Journal of medical biochemistry · 2026
Changes in serum pain mediators, stress response, inflammatory markers, and coagulation function in lumbar disc herniation patients treated by musculoskeletal ultrasound-guided needle-knife.
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Wu Jiaqi, Chen Ming, Liu Wenlong, Jiang Jiaming, Chen Sihan, Liu Tingyu, Liu Xiaoyan
Аннотация
BACKGROUND: To investigate the impacts of musculoskeletal ultrasound (MSK-US)-guided needle-knife on serum pain mediators, stress response, inflammatory markers, and coagulation function in lumbar disc herniation (LDH) patients.
METHODS: In this prospective cohort study, we recruited 100 LDH patients admitted between February 2024 and January 2025 and assigned them to an MSK-US group (52 cases undergoing MSK-US-guided needle-knife) and a conventional group (48 cases receiving conventional needle-knife). Peripheral venous blood was collected before and within 2 hours postoperatively for IL-6, TNF-a, SP 5-HT, and hs-CRP measurements by ELISA, Cor, E, and NE determination using an automatic biochemical analyzer, b-EP detection by chemiluminescent immunoassay, and APTT, PT, FIB, and D-D quantification with a coagulation analyzer. Dynamic changes in these biomarkers were analyzed by betweenand within-group comparisons.
RESULTS: Both groups demonstrated postoperative reductions in SP and 5-HT and an elevation in b-EP (P< 0.05), though no marked inter-group differences were noted (P> 0.05). The MSK-US group showed lower postoperative levels of Cor, E, NE, IL-6, hs-CRP D-D, and FIB than the conventional group (P< 0.05), suggesting MSK-US's ability to reduce inflammation, alleviate stress reaction, and lower hyperfibrinolysis risk.
CONCLUSIONS: MSK-US-guided needle-knife is effective in mitigating perioperative stress response and systemic inflammation in LDH patients while reducing the risk of coagulation disorders and providing a biomarker-driven framework for personalized postoperative management.
METHODS: In this prospective cohort study, we recruited 100 LDH patients admitted between February 2024 and January 2025 and assigned them to an MSK-US group (52 cases undergoing MSK-US-guided needle-knife) and a conventional group (48 cases receiving conventional needle-knife). Peripheral venous blood was collected before and within 2 hours postoperatively for IL-6, TNF-a, SP 5-HT, and hs-CRP measurements by ELISA, Cor, E, and NE determination using an automatic biochemical analyzer, b-EP detection by chemiluminescent immunoassay, and APTT, PT, FIB, and D-D quantification with a coagulation analyzer. Dynamic changes in these biomarkers were analyzed by betweenand within-group comparisons.
RESULTS: Both groups demonstrated postoperative reductions in SP and 5-HT and an elevation in b-EP (P< 0.05), though no marked inter-group differences were noted (P> 0.05). The MSK-US group showed lower postoperative levels of Cor, E, NE, IL-6, hs-CRP D-D, and FIB than the conventional group (P< 0.05), suggesting MSK-US's ability to reduce inflammation, alleviate stress reaction, and lower hyperfibrinolysis risk.
CONCLUSIONS: MSK-US-guided needle-knife is effective in mitigating perioperative stress response and systemic inflammation in LDH patients while reducing the risk of coagulation disorders and providing a biomarker-driven framework for personalized postoperative management.