Photodermatology, photoimmunology & photomedicine · 2025
The Efficacy of Intense Pulsed Light Versus Topical Nicotinamide 4% in Treatment of Acne Vulgaris.
СтатьяСравнительное исследованиеКлиническое исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Al-Sharnoby Hagar Atteya, Al-Bakary Reda Hassan, Nassar Samia Othman, Mesbah Reem Adel Mahmoud
Аннотация
BACKGROUND: Intense pulsed light (IPL) is a Food and Drug Administration-approved device for the management of several dermatologic disorders, including Acne vulgaris (AV). Nicotinamide, a form of vitamin B3, constitutes a possible therapeutic approach for AV. It has powerful anti-inflammatory benefits without the danger of bacterial resistance or systemic adverse effects.
PURPOSE: To contrast the efficacy and safety of IPL and topical nicotinamide 4% cream in the management of AV.
METHODS: This comparative work was conducted on 20 participants aged from 18 to 40 years both sexes, with different clinical types of AV. The patients' faces were allocated into two sides: The right side of the face was treated with 4 IPL sessions at two-weeks intervals, while the left side was treated with topical nicotinamide 4% cream twice daily for 2 months. Clinical assessment of acne lesions in all patients was performed before starting treatment and one and 3 months after the last session.
RESULTS: A significant enhancement of inflammatory acne lesions existed after treatment with IPL and nicotinamide 4% topical cream. A significant variation existed between the two sides of the face after treatment according to the degree of enhancement, in which the IPL showed better improvement than the nicotinamide 4% cream. Moreover, patients were more satisfied with IPL treatment.
CONCLUSIONS: IPL seems to be a safe and effective therapy in the management of mild to moderate inflammatory acne and an alternative to other systemic modalities of acne treatment when they are contraindicated.
PURPOSE: To contrast the efficacy and safety of IPL and topical nicotinamide 4% cream in the management of AV.
METHODS: This comparative work was conducted on 20 participants aged from 18 to 40 years both sexes, with different clinical types of AV. The patients' faces were allocated into two sides: The right side of the face was treated with 4 IPL sessions at two-weeks intervals, while the left side was treated with topical nicotinamide 4% cream twice daily for 2 months. Clinical assessment of acne lesions in all patients was performed before starting treatment and one and 3 months after the last session.
RESULTS: A significant enhancement of inflammatory acne lesions existed after treatment with IPL and nicotinamide 4% topical cream. A significant variation existed between the two sides of the face after treatment according to the degree of enhancement, in which the IPL showed better improvement than the nicotinamide 4% cream. Moreover, patients were more satisfied with IPL treatment.
CONCLUSIONS: IPL seems to be a safe and effective therapy in the management of mild to moderate inflammatory acne and an alternative to other systemic modalities of acne treatment when they are contraindicated.