Skin-associated commensal microorganisms and their metabolites.

The skin microbiome is an essential component on our skin and is critical for the maintenance of skin health. It consists of a diverse ecosystem of bacteria, fungi, and viruses. Different body sites in humans exhibit vastly different levels of sebum, temperature, and pH, therefore the microbes that colonize these areas have adapted to create a niche for colonization. Healthy microbial diversity is important in the normal function of the skin, and imbalances in microbial diversity in the skin microbiome have been found to correlate with several skin diseases, such as atopic dermatitis, acne vulgaris, psoriasis, and chronic wound infections. These microorganisms, especially commensal bacteria, produce various metabolites such as short-chain fatty acids, antimicrobial peptides, siderophores, and tryptophan-derived metabolites. These metabolites can interact with and aid the host in processes, such as wound healing and colonization resistance. Metabolites produced by skin commensals have promising therapeutical potential for drug-resistant bacterial infections in place of conventional antibiotics to combat widespread antibiotic resistance. In this review, we will discuss the composition of the skin microbiota and the different classes of metabolites produced by its members, as well as how changes in the skin microbiome impact certain disease conditions.