Modulatory effects of transcranial magneto-acoustic stimulation on behavior and corticostriatal transmission of oscillatory activity in a mouse model of Parkinson's disease induced by MPTP.

BACKGROUND

Transcranial magneto-acoustic stimulation (TMAS) is a novel noninvasive neuromodulation technology that combines ultrasound within a static magnetic field to achieve high spatial resolution and deep brain penetration. However, the effects of TMAS on neural oscillations related to motor deficits in Parkinson's disease (PD) remain poorly understood.

OBJECTIVE

The objective of this study was to investigate whether TMAS could enhance the propagation and interaction of oscillatory dynamics within the corticostriatal circuit.

METHODS

We performed a comprehensive neurological assessment using behavioral tests, in vivo electrophysiological recordings, and immunohistochemistry in male C57BL/6 J mice treated with MPTP, followed by noninvasive brain stimulation.

RESULTS

Our results demonstrate that TMAS: 1) improves locomotor performance and learning abilities in PD mice; 2) reduces phase-amplitude coupling between beta and gamma frequency bands of local field potentials, while enhancing inter-brain interactions and information transmission; 3) modulates neural activity and depresses c-Fos overexpression on the dorsal striatum of PD mice; 4) provides neuroprotection by modulating neuroinflammation and mitigating MPTP-induced neurotoxicity within neural circuits.

CONCLUSION

These findings highlight the role of TMAS in strengthening the functional organization of the corticostriatal circuit, suggesting its potential as a novel treatment for neuropsychiatric disorders characterized by activity disruptions.