Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao · 1993
[The number, distribution and effects of interleukin-2 receptor and CD4 antigens in benign and malignant lymphoproliferative diseases].
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Liu W, Su Z, Wang L, Xu S, Chen Q, Zhang Z
Аннотация
An analysis of immunophenotypes was made in benign and malignant lymphoproliferative diseases (35 cases) and short cultured lymphocytes of chronic tonsillitis (15 cases). The number, distribution and variation of interleukin-2 receptor (IL-2R, CD25) and CD4 positive cells in the above lesions were studied. The results showed that (1) there were more or less IL-2R+ and CD4+ cells presented in the tissues of benign lymphoproliferative lesions; (2) IL-2R antigen was also presented in some tumor and non-tumor cells with CD4+ reaction but it was not found in the cells with CD1+ or/and CD8+ reactions; (3) IL-2R and CD4 antigens were expressed in the proliferated lymphocytes stimulated by PHA. Although IL-2R antigen is not a specific marker to certain types of lymphocytes, it has some relations with immunophenotypes of lymphocytes. The functions and effects of IL-2, IL-2R and helper T lymphocytes were also discussed.