[The number, distribution and effects of interleukin-2 receptor and CD4 antigens in benign and malignant lymphoproliferative diseases].

An analysis of immunophenotypes was made in benign and malignant lymphoproliferative diseases (35 cases) and short cultured lymphocytes of chronic tonsillitis (15 cases). The number, distribution and variation of interleukin-2 receptor (IL-2R, CD25) and CD4 positive cells in the above lesions were studied. The results showed that (1) there were more or less IL-2R+ and CD4+ cells presented in the tissues of benign lymphoproliferative lesions; (2) IL-2R antigen was also presented in some tumor and non-tumor cells with CD4+ reaction but it was not found in the cells with CD1+ or/and CD8+ reactions; (3) IL-2R and CD4 antigens were expressed in the proliferated lymphocytes stimulated by PHA. Although IL-2R antigen is not a specific marker to certain types of lymphocytes, it has some relations with immunophenotypes of lymphocytes. The functions and effects of IL-2, IL-2R and helper T lymphocytes were also discussed.