The Role of [99mTc]Tc-Sestamibi in Functional Imaging of the Iodine-Loaded Thyroid Gland.

Due to high iodine loading from iodinated contrast media, the thyroid uptake of common radiopharmaceuticals ([99mTc]NaTcO4 and [123I]NaI) can be influenced up to 2 mo after administration. In such cases, and generally when differential diagnosis between productive and destructive thyrotoxicosis is necessary, [99mTc]Tc-sestamibi scintigraphy could be an option. This case highlights the role of [99mTc]Tc-sestamibi in the evaluation of thyrotoxicosis in a patient with a blocked thyroid gland as a result of stable iodine saturation.