Experimental cerebral atherosclerosis in the dog. I. A morphologic study.

Prolonged feeding with an atherogenic diet can induce occlusive disease of the intracranial arteries and cerebral infarction in dogs. The morphologic findings suggest that separation of the internal elastic lamina from the endothelial basement membrane is a consistent change and probably an initiating mechanism in the pathogenesis of atherosclerosis of the cerebral arteries.