Safety, Feasibility, and Diagnostic Yield of Invasive Coronary Function Testing: Netherlands Registry of Invasive Coronary Vasomotor Function Testing.
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Crooijmans Caïa, Jansen Tijn P J, Meeder Joan G, Woudstra Janneke, Meuwissen Martijn, De Vos Annemiek M J, Paradies Valeria, Olde Bijvank Els G M, Winkler Patty, Vos Nicola S, Arkenbout Karin, Woudstra Pier, Stoel Martin G, Van de Hoef Tim P, Van den Oord Stijn C H, Widdershoven Jos W M G, Remkes Wouter, Cetinyurek-Yavuz Aysun, Den Ruijter Hester M, Onland-Moret N Charlotte, Boersma Eric, Beijk Marcel A M, Appelman Yolande, Piek Jan J, Konst Regina E, Maas Angela H E M, Van Royen Niels, Dimitriu-Leen Aukelien C, Elias-Smale Suzette E, Damman Peter, NL-CFT Investigators
Аннотация
OBJECTIVE: To determine the prevalence of vasomotor dysfunction in patients with angina and no obstructive coronary artery disease who were clinically referred for a coronary function test (CFT); and assess safety and feasibility of a CFT.
DESIGN, SETTING, AND PARTICIPANTS: This quality improvement study was performed using the Netherlands Registry of Invasive Coronary Vasomotor Function Testing (NL-CFT), a prospective, observational registry, in 15 participating hospitals (2 tertiary and 13 nontertiary). Patients with angina and no obstructive coronary artery disease who were referred for a clinically indicated CFT between December 2020 and January 2024 were included.
MAIN OUTCOMES AND MEASURES: A complete CFT consisted of acetylcholine spasm provocation testing and assessment of microcirculatory function. Prevalence of different endotypes based on test results and overall safety were assessed.
RESULTS: Among a total of 1207 patients included, 978 (81%) were female; and the mean (SD) age was 60 (10) years. The prevalence of coronary vasomotor dysfunction was very high (78%). There were 11 (0.9%) major and 10 (0.8%) minor complications reported. Of them, 3 major and all minor were definitely related to the coronary function test. No procedural death, myocardial infarction, or stroke was observed. No differences were found in the occurrence of complications between tertiary and nontertiary centers.
CONCLUSIONS AND RELEVANCE: This study found that a CFT was feasible and safe to perform in both tertiary and nontertiary centers with a high diagnostic yield.