Clinical outcome measures.

The typical fluctuating skeletal muscle weakness in myasthenia gravis can make measuring disease severity challenging. Multiple measures have been developed to assess the signs and symptoms of myasthenia, from pure examination measures to fully patient-reported measures to combinations. There are also measures aimed at assessing quality of life and satisfaction. Electrophysiology and serology have also been used in some studies as surrogate outcomes. In this chapter, we review outcomes specifically developed to assess disease severity in myasthenia, as well as quality of life, and data on electrophysiology and serology as outcome measures.