Exercise and myasthenia gravis.

The role of non-pharmacological management in MG is currently underdeveloped and underutilized. Exercise training has been shown to be both feasible and beneficial in improving function and strength in individuals with MG. Observational studies indicate that physical activity is associated with reduced perceived fatigue. Barriers to exercise persist in MG, and should be addressed by healthcare professionals. Maintaining or increasing muscle strength and endurance as well as cardiorespiratory fitness should be prioritized regardless of current level of function. In the general population, exercise has the potential to reduce anxiety and depression although studies in MG are still lacking. Exercise programs should be individualized and progressive, with a clear emphasis on reducing sedentary behavior. Current research has primarily focused on individuals with mild-moderate MG. Further studies are needed to understand the potential impact of exercise training on enhancing pharmacological therapies and the potential role of exercise in immunomodulation in MG. This chapter reviews the existing literature on exercise in MG.