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DOI 10.1080/09273948.2018.1489061

Медицинская библиотека · Ocular immunology and inflammation · 2018

The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Description of the Spectrum of Choroidal Involvement in 245 Patients with Tubercular Uveitis.

Agrawal Rupesh, Gunasekeran Dinesh Visva, Agarwal Aniruddha, Carreño Ester, Aggarwal Kanika, Gupta Bhaskar, Raje Dhananjay, Murthy Somasheila I, Westcott Mark, Chee Soon Phaik, McCluskey Peter, Ling Ho Su, Teoh Stephen, Cimino Luca, Biswas Jyotirmay, Narain Shishir, Agarwal Manisha, Mahendradas Padmamalini, Khairallah Moncef, Jones Nicholas, Tugal-Tutkun Ilknur, Babu Kalpana, Basu Soumayava, Lee Richard, Al-Dhibi Hassan, Bodaghi Bahram, Invernizzi Alessandro, Goldstein Debra A, Herbort Carl P, Barisani-Asenbauer Talin, González-López Julio J, Androudi Sofia, Bansal Reema, Moharana Bruttendu, Mahajan Sarakshi, Esposti Simona, Tasiopoulou Anastasia, Nadarajah Sengal, Agarwal Mamta, Abraham Sharanya, Vala Ruchi, Lord Joanne, Singh Ramandeep, Sharma Aman, Sharma Kusum, Zierhut Manfred, Kon Onn Min, Kempen John, Cunningham Emmett T, Rousselot Andres, Nguyen Quan Dong, Pavesio Carlos, Gupta Vishali

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Аннотация

Purpose: To contribute a global description of the spectrum of choroidal involvement in tubercular uveitis (TBU).

Methods

Retrospective cohort study of TBU patients with choroidal involvement from 25 centers between January 2004 and December 2014. Medical records of patients with a minimum follow-up of 1 year were reviewed.

Results

245 patients were included. The phenotypic variations included serpiginous-like choroiditis (SLC) (46%), tuberculoma (13.5%), multifocal choroiditis (MFC) (9.4%), ampiginous choroiditis (9%), among others. 219 patients were treated with anti-tubercular therapy (ATT) (n = 219/245, 89.38%), 229 patients with steroids (n = 229/245, 93.47%) and 28 patients with immunosuppressive agents (n = 28/245, 11.42%). Treatment failure was noted in 38 patients (n = 38/245, 15.5%). Patients with SLC and ampiginous choroiditis appeared to have superior outcomes on survival analysis (p = 0.06).

Conclusion

This study provides a comprehensive description of choroidal involvement in TBU. Patients with SLC and ampiginous choroiditis may have better clinical outcomes.

Для цитирования: Agrawal Rupesh, Gunasekeran Dinesh Visva, Agarwal Aniruddha, Carreño Ester, Aggarwal Kanika, Gupta Bhaskar, Raje Dhananjay, Murthy Somasheila I, Westcott Mark, Chee Soon Phaik, McCluskey Peter, Ling Ho Su, Teoh Stephen, Cimino Luca, Biswas Jyotirmay, Narain Shishir, Agarwal Manisha, Mahendradas Padmamalini, Khairallah Moncef, Jones Nicholas, Tugal-Tutkun Ilknur, Babu Kalpana, Basu Soumayava, Lee Richard, Al-Dhibi Hassan, Bodaghi Bahram, Invernizzi Alessandro, Goldstein Debra A, Herbort Carl P, Barisani-Asenbauer Talin, González-López Julio J, Androudi Sofia, Bansal Reema, Moharana Bruttendu, Mahajan Sarakshi, Esposti Simona, Tasiopoulou Anastasia, Nadarajah Sengal, Agarwal Mamta, Abraham Sharanya, Vala Ruchi, Lord Joanne, Singh Ramandeep, Sharma Aman, Sharma Kusum, Zierhut Manfred, Kon Onn Min, Kempen John, Cunningham Emmett T, Rousselot Andres, Nguyen Quan Dong, Pavesio Carlos, Gupta Vishali. The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Description of the Spectrum of Choroidal Involvement in 245 Patients with Tubercular Uveitis.. Ocular immunology and inflammation. 2018. DOI: 10.1080/09273948.2018.1489061.
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