American journal of translational research · 2023
Safety of photodynamic therapy combined with surgical excision in patients with actinic keratosis and risk factors for secondary cutaneous squamous cell carcinoma.
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Yi Qin, Liu Jiayan
Аннотация
OBJECTIVE: To investigate the efficacy of photodynamic therapy combined with surgical excision on the prognosis of patients with actinic keratosis (AK) and to analyze the risk factors for secondary cutaneous squamous cell carcinoma (cSCC).
METHODS: Clinical data of 114 patients with AK treated at the West China Hospital from March 2014 to November 2018 were enrolled to this retrospective analysis. Among them 55 patients who underwent surgical resection alone were the control group (CG) and the other 59 who received photodynamic therapy combined with surgical resection were in the research group (RG). The treatment efficacy, lesion area, quality of life, incidence of adverse effects, and incidence of secondary sSCC in 3 years were compared, and the risk factors for sSCC were analyzed by multivariate logistics analysis.
RESULTS: The treatment efficacy of the RG was dramatically higher than that of the CG (P<0.05), and there was no obvious difference in the incidence of adverse reactions between the two groups (P>0.05). The lesion area and dermatology life quality index of the RG were dramatically lower than those of the CG after treatment (P<0.05), and the 3-year incidence of secondary cSCC in the RG was not statistically different from that of the OG (P>0.05). A greater number of lesion sites, a family history of tumor, and a history of skin disease were independent risk factors for secondary cSCC.
CONCLUSION: Photodynamic therapy combined with surgical excision has better therapeutic efficacy in AK with a high safety.
METHODS: Clinical data of 114 patients with AK treated at the West China Hospital from March 2014 to November 2018 were enrolled to this retrospective analysis. Among them 55 patients who underwent surgical resection alone were the control group (CG) and the other 59 who received photodynamic therapy combined with surgical resection were in the research group (RG). The treatment efficacy, lesion area, quality of life, incidence of adverse effects, and incidence of secondary sSCC in 3 years were compared, and the risk factors for sSCC were analyzed by multivariate logistics analysis.
RESULTS: The treatment efficacy of the RG was dramatically higher than that of the CG (P<0.05), and there was no obvious difference in the incidence of adverse reactions between the two groups (P>0.05). The lesion area and dermatology life quality index of the RG were dramatically lower than those of the CG after treatment (P<0.05), and the 3-year incidence of secondary cSCC in the RG was not statistically different from that of the OG (P>0.05). A greater number of lesion sites, a family history of tumor, and a history of skin disease were independent risk factors for secondary cSCC.
CONCLUSION: Photodynamic therapy combined with surgical excision has better therapeutic efficacy in AK with a high safety.