Journal of neuroimmunology · 2025
Elevated serum levels of IL-10 family and IL-12 family cytokines in myasthenia gravis.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Onishi Yosuke, Uzawa Akiyuki, Yasuda Manato, Akamine Hiroyuki, Ogaya Etsuko, Handa Hideo, Ozawa Yukiko, Kuwabara Satoshi
Аннотация
BACKGROUND: IL-10 and IL-12 family cytokines play important roles in various immunological diseases. This study identified a relationship between IL-10 and IL-12 family cytokines and the pathogenesis of myasthenia gravis (MG).
METHODS: We measured IL-10 and IL-12 family cytokines levels in 25 treatment-naive MG patients with acetylcholine receptor (AChR) antibodies and 28 controls and examined their relationships with clinical parameters.
RESULTS: Serum levels of IL-10, IL-12p40, IL-12p70, IL-20, IL-22, IL-26, IL-28A, IL-29, and IL-35 were significantly higher in MG group than in control group. Among these, IL-20, IL-26, IL-28A, and IL-29 levels decreased after immunotherapy. AChR antibody titers were negatively correlated with levels of IL-12p40, IL-22, and IL-26. Scores on the MG activities of daily living (MG-ADL) scale were negatively correlated with IL-20 levels.
CONCLUSION: Serum levels of IL-10 and IL-12 family cytokines were elevated in MG. In particular, IL-12p40, IL-20, IL-22, and IL-26 levels might be potential disease biomarkers in MG patients.
METHODS: We measured IL-10 and IL-12 family cytokines levels in 25 treatment-naive MG patients with acetylcholine receptor (AChR) antibodies and 28 controls and examined their relationships with clinical parameters.
RESULTS: Serum levels of IL-10, IL-12p40, IL-12p70, IL-20, IL-22, IL-26, IL-28A, IL-29, and IL-35 were significantly higher in MG group than in control group. Among these, IL-20, IL-26, IL-28A, and IL-29 levels decreased after immunotherapy. AChR antibody titers were negatively correlated with levels of IL-12p40, IL-22, and IL-26. Scores on the MG activities of daily living (MG-ADL) scale were negatively correlated with IL-20 levels.
CONCLUSION: Serum levels of IL-10 and IL-12 family cytokines were elevated in MG. In particular, IL-12p40, IL-20, IL-22, and IL-26 levels might be potential disease biomarkers in MG patients.