Psychiatrische Praxis · 2010
[Risperidone intoxication in a patient with a genetic predisposition as "poor [non]metabolizer"].
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Strauss Maria, Heinritz Wolfram, Hegerl Ulrich, Kopf Andrea
Аннотация
OBJECTIVE: The enzyme system cytochrome P450 plays a central role in the metabolism of drugs in the human body. The enzyme CYP2D6 is important for the metabolism of psychoactive agents. Genetic changes in the CYP2D6 gene can lead to reduced or absent activity.
METHODS: We report on a 37-year-old female patient who was given risperidone to treat an acute delusional disorder. Despite receiving a very low dose, the patient suffered from an intoxication. We inferred that an excessively raised plasma level of risperidone may result from a pharmacologically relevant disorder of metabolism.
RESULTS: The molecular genetic investigation revealed a compound heterozygous mutation in the CYP2D6 gene and thus documented a genetic predisposition as a "poor [non]metabolizer".
CONCLUSIONS: In intoxications with psychoactive agents, the presence of an enzyme defect in the P450 system should be considered as an additional possible cause.
METHODS: We report on a 37-year-old female patient who was given risperidone to treat an acute delusional disorder. Despite receiving a very low dose, the patient suffered from an intoxication. We inferred that an excessively raised plasma level of risperidone may result from a pharmacologically relevant disorder of metabolism.
RESULTS: The molecular genetic investigation revealed a compound heterozygous mutation in the CYP2D6 gene and thus documented a genetic predisposition as a "poor [non]metabolizer".
CONCLUSIONS: In intoxications with psychoactive agents, the presence of an enzyme defect in the P450 system should be considered as an additional possible cause.
Предметные рубрики MeSH
AdultAntipsychotic AgentsChromosomes, Human, Pair 22CyclohexanolsCytochrome P-450 CYP2D6DNA Mutational AnalysisDelusionsDose-Response Relationship, DrugDrug MonitoringDrug Therapy, CombinationExonsFemaleGenetic Carrier ScreeningHumansInactivation, MetabolicIntronsMetabolic Clearance RatePsychotic DisordersRisperidoneSelective Serotonin Reuptake InhibitorsVenlafaxine Hydrochloride