Developments in biological standardization · 1978
A two-dose schedule for immunization of infants using a more concentrated DPT-vaccine.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод в очереди
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Mangay-Angara A, Fulgencio L, Casabal G, Gudani L, Sumpaico J, Ocampo A, Nagel J, Hagenaars A M, van Hemert P A, Cohen H
Аннотация
In a controlled field-trial in infants in the Philippines, a two-dose schedule with an interval of 6 months between injections using a concentrated adsorbed DPT-vaccine was evaluated. The serologic response against the three components in the vaccine was satisfactory, whereas the side-effects in the concentrated vaccine group did not differ from those observed in a control DPT group. After two injections, the coverage percentage with DPT-vaccine was shown to be higher than 70%. Two implications of the introduction of the two-dose DPT-immunization schedule are discussed, i.e. (a) the possibility of using it as the nucleus of a complete schedule including immunization against poliomyelitis, BCG, smallpox and measles, and (b) the consequences which the interval of 6 months might have on the epidemiological spread of B. pertussis infections.