European journal of radiology · 2024
CT-based airway changes after smoking cessation in the general population.
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Dudurych Ivan, Sidorenkov Grigory, van Tuinen Marcel, Slebos Dirk-Jan, de Bock Geertruida H, van den Berge Maarten, de Bruijne Marleen, Vliegenthart Rozemarijn
Аннотация
PURPOSE: Previous research has demonstrated improvements in CT-derived bronchial parameters in the first years after smoking cessation. This study investigates the association between longer smoking cessation duration and bronchial parameters in lung-healthy and lung-unhealthy ex-smokers from the general population.
MATERIALS AND METHODS: We conducted a cross-sectional analysis using low-dose CT scans of ex-smokers from the general population with at least 10 pack-years from the ImaLife study, a sub study within the Lifelines cohort. Participants ⩾45 years who completed a lung-function test were recruited for low-dose CT imaging. We divided them into lung-healthy and lung-unhealthy based on spirometry, self-reported diagnosis and imaging signs of respiratory disease. Bronchial parameters Pi10, wall thickness, luminal area and wall area percent (WAP) were obtained using a previously validated method. Multivariable linear regression (MLR) was used to evaluate the independent associations between smoking cessation duration and bronchial parameters, adjusting for sex, age, height, weight, and pack-years.
RESULTS: The study included 1,869 ex-smokers; 1,421 (76 %) were classified as lung-healthy (58 % men, mean age 64.2 ± 9.8 years, pack-years 16.5 [12.5-23.3], smoking cessation duration 20.0 [14.0-29.0] years) and 448 (24 %) as unhealthy (56 % men, mean age 66.1 ± 10.5 years, pack-years 18.2 [13.4-25.2], smoking cessation duration 20.0 [13.8-29.0] years). In the lung-unhealthy group, individuals with a longer duration of smoking cessation had a lower WAP compared to those with a shorter cessation duration (-0.528 % per 10 years, p = 0.005). In contrast, in MLR no significant associations were observed for the lung-healthy group..
CONCLUSIONS: In individuals with respiratory conditions, longer smoking cessation duration is related to a decrease in wall area percent of the bronchial walls. The results suggest the potential for improvements in airway health when people quit smoking, warranting further investigation with longitudinal studies.
MATERIALS AND METHODS: We conducted a cross-sectional analysis using low-dose CT scans of ex-smokers from the general population with at least 10 pack-years from the ImaLife study, a sub study within the Lifelines cohort. Participants ⩾45 years who completed a lung-function test were recruited for low-dose CT imaging. We divided them into lung-healthy and lung-unhealthy based on spirometry, self-reported diagnosis and imaging signs of respiratory disease. Bronchial parameters Pi10, wall thickness, luminal area and wall area percent (WAP) were obtained using a previously validated method. Multivariable linear regression (MLR) was used to evaluate the independent associations between smoking cessation duration and bronchial parameters, adjusting for sex, age, height, weight, and pack-years.
RESULTS: The study included 1,869 ex-smokers; 1,421 (76 %) were classified as lung-healthy (58 % men, mean age 64.2 ± 9.8 years, pack-years 16.5 [12.5-23.3], smoking cessation duration 20.0 [14.0-29.0] years) and 448 (24 %) as unhealthy (56 % men, mean age 66.1 ± 10.5 years, pack-years 18.2 [13.4-25.2], smoking cessation duration 20.0 [13.8-29.0] years). In the lung-unhealthy group, individuals with a longer duration of smoking cessation had a lower WAP compared to those with a shorter cessation duration (-0.528 % per 10 years, p = 0.005). In contrast, in MLR no significant associations were observed for the lung-healthy group..
CONCLUSIONS: In individuals with respiratory conditions, longer smoking cessation duration is related to a decrease in wall area percent of the bronchial walls. The results suggest the potential for improvements in airway health when people quit smoking, warranting further investigation with longitudinal studies.