Irish journal of medical science · 2026
Association between cataract and ischemic stroke risk in middle-aged adults: a retrospective cohort study in Taiwan.
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Lai Shih-Wei, Kuo Yu-Hung, Liao Kuan-Fu
Аннотация
OBJECTIVE: This cohort study aimed to investigate whether patients with cataract had an increased risk of ischemic stroke in Taiwan.
METHODS: This study was conducted using electronic health records from Taiwan's National Health Insurance Research Database (NHIRD) over an eight-year period (2013-2020). Patients aged 40-64 years with newly diagnosed cataract were selected as the cataract group. Patients who had at least one ophthalmology visit but no diagnosis of cataract were selected as the non-cataract group from the same database. Both cataract and non-cataract groups were matched for sex, age, and baseline comorbidities using a 1:1 propensity score matching. The risk of ischemic stroke was compared between the two groups using a Cox proportional hazards model, adjusting for potential confounders.
RESULTS: The cohort study included 649,404 patients in the cataract group and 649,404 patients in the non-cataract group. The mean age was 57 years, and approximately 41.3% were male in both groups. The incidence rates of ischemic stroke were 6.12 per 1000 person-years in the cataract group and 4.48 per 1000 person-years in the non-cataract group (incidence rate ratio = 1.37, 95% CI = 1.34-1.40, P < 0.001). After adjusting for potential confounders, the hazard ratio for ischemic stroke was 1.33 in patients with cataract when compared to those without cataract (95% CI = 1.30-1.36, P < 0.001).
CONCLUSION: Our cohort study found that patients with cataract aged 40-64 years had an increased risk of ischemic stroke. These findings highlight the importance of recognizing this elevated risk in patients with cataract.
METHODS: This study was conducted using electronic health records from Taiwan's National Health Insurance Research Database (NHIRD) over an eight-year period (2013-2020). Patients aged 40-64 years with newly diagnosed cataract were selected as the cataract group. Patients who had at least one ophthalmology visit but no diagnosis of cataract were selected as the non-cataract group from the same database. Both cataract and non-cataract groups were matched for sex, age, and baseline comorbidities using a 1:1 propensity score matching. The risk of ischemic stroke was compared between the two groups using a Cox proportional hazards model, adjusting for potential confounders.
RESULTS: The cohort study included 649,404 patients in the cataract group and 649,404 patients in the non-cataract group. The mean age was 57 years, and approximately 41.3% were male in both groups. The incidence rates of ischemic stroke were 6.12 per 1000 person-years in the cataract group and 4.48 per 1000 person-years in the non-cataract group (incidence rate ratio = 1.37, 95% CI = 1.34-1.40, P < 0.001). After adjusting for potential confounders, the hazard ratio for ischemic stroke was 1.33 in patients with cataract when compared to those without cataract (95% CI = 1.30-1.36, P < 0.001).
CONCLUSION: Our cohort study found that patients with cataract aged 40-64 years had an increased risk of ischemic stroke. These findings highlight the importance of recognizing this elevated risk in patients with cataract.