The Journal of hospital infection · 2025
Exploring the bactericidal efficacy of a new potassium monopersulphate-based disinfectant.
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Barbosa P P, Leme D M, Motta N G, Magalhães W L E, Proenca-Modena J L, Maillard J-Y
Аннотация
BACKGROUND: Staphylococcus aureus and Klebsiella pneumoniae are common pathogens responsible for hospital-acquired infections. Both species can survive on surfaces following desiccation and form dry surface biofilms (DSBs), which complicates the disinfection process.
AIM: To evaluate the efficacy of an innovative potassium monopersulphate-based nanotechnology formulation (MPS) against both planktonic and sessile S. aureus and K. pneumoniae.
METHODS: The bactericidal efficacy of MPS was tested in comparison with sodium hypochlorite (NaOCl) and didecyldimethylammonium chloride (DDAC), which served as controls. The assessment was performed against planktonic bacteria, hydrated biofilm, and DSB using standard suspension and carrier tests. Scanning electron microscopy (SEM) was employed to identify any gross structural damage.
FINDINGS: MPS (2% w/v) achieved a ≥4 log10 reduction in K. pneumoniae with a short contact time, regardless of the test protocol. S. aureus was more resilient, but the introduction of wiping reduced the contact time needed to achieve a 4 log10 reduction from 15 to 5 min. SEM analysis revealed gross structural damage in both species following MPS treatment. The other disinfectants tested were also bactericidal, achieving ≥4 log10 reduction within 1-5 min, with the exception of DDAC against hydrated biofilms.
CONCLUSION: The potassium monopersulphate-based formulation was found to be an effective bactericide, including against DSBs. Its efficacy compares favourably with other biocides commonly used in healthcare settings, and its biodegradability makes it a promising candidate for further development. However, optimization of the mechanical removal process will be essential to enhance MPS efficacy in practical applications.
AIM: To evaluate the efficacy of an innovative potassium monopersulphate-based nanotechnology formulation (MPS) against both planktonic and sessile S. aureus and K. pneumoniae.
METHODS: The bactericidal efficacy of MPS was tested in comparison with sodium hypochlorite (NaOCl) and didecyldimethylammonium chloride (DDAC), which served as controls. The assessment was performed against planktonic bacteria, hydrated biofilm, and DSB using standard suspension and carrier tests. Scanning electron microscopy (SEM) was employed to identify any gross structural damage.
FINDINGS: MPS (2% w/v) achieved a ≥4 log10 reduction in K. pneumoniae with a short contact time, regardless of the test protocol. S. aureus was more resilient, but the introduction of wiping reduced the contact time needed to achieve a 4 log10 reduction from 15 to 5 min. SEM analysis revealed gross structural damage in both species following MPS treatment. The other disinfectants tested were also bactericidal, achieving ≥4 log10 reduction within 1-5 min, with the exception of DDAC against hydrated biofilms.
CONCLUSION: The potassium monopersulphate-based formulation was found to be an effective bactericide, including against DSBs. Its efficacy compares favourably with other biocides commonly used in healthcare settings, and its biodegradability makes it a promising candidate for further development. However, optimization of the mechanical removal process will be essential to enhance MPS efficacy in practical applications.