Cureus · 2025
Etiological Profile and Antibiotic Susceptibility of Urinary Isolates Causing Urinary Tract Infections in Patients Attending a Tertiary Care Hospital in Rajkot, Gujarat.
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Bhise Mayuri, Chauhan Kinjal, Anandani Garima, Agarwal Ashwini
Аннотация
OBJECTIVES: This study aims to determine the occurrence of urinary tract infections (UTIs) and the bacteriological spectrum in urine samples, as well as to assess the antibiotic susceptibility patterns of the isolates.
MATERIALS AND METHODS: A retrospective study (October 2022 to October 2024) was conducted in the microbiology department, analyzing urine sample records using biochemical techniques and antimicrobial susceptibility testing guided by the Clinical and Laboratory Standards Institute. Data analysis was performed using SPSS Statistics version 23 (IBM Corp., 2015).
RESULTS: Among 1,027 samples, 13.43% yielded positive cultures. Most infections occurred in females (64.49%), particularly those aged 51-70 (56%). Gram-negative bacteria (89.13%), predominantly Escherichia coli and Klebsiella pneumoniae, were more common than Gram-positive bacteria (9.42%). Effective antibiotics included fosfomycin (85.97%), gentamicin (90%), and nitrofurantoin (77.6%).
CONCLUSIONS: UTIs in this region are largely caused by Gram-negative bacteria, primarily Escherichia coli. Nitrofurantoin and fosfomycin are recommended for initial treatment. These findings support the development of empirical treatment protocols for the region.
MATERIALS AND METHODS: A retrospective study (October 2022 to October 2024) was conducted in the microbiology department, analyzing urine sample records using biochemical techniques and antimicrobial susceptibility testing guided by the Clinical and Laboratory Standards Institute. Data analysis was performed using SPSS Statistics version 23 (IBM Corp., 2015).
RESULTS: Among 1,027 samples, 13.43% yielded positive cultures. Most infections occurred in females (64.49%), particularly those aged 51-70 (56%). Gram-negative bacteria (89.13%), predominantly Escherichia coli and Klebsiella pneumoniae, were more common than Gram-positive bacteria (9.42%). Effective antibiotics included fosfomycin (85.97%), gentamicin (90%), and nitrofurantoin (77.6%).
CONCLUSIONS: UTIs in this region are largely caused by Gram-negative bacteria, primarily Escherichia coli. Nitrofurantoin and fosfomycin are recommended for initial treatment. These findings support the development of empirical treatment protocols for the region.