Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2004
Hearing loss with semicircular canal transection and Pseudomonas aeruginosa otitis media.
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Prevatt Angela R, Sedwick Jack D, Gajewski Byron J, Antonelli Patrick J
Аннотация
OBJECTIVE: To determine if Pseudomonas aeruginosa (PA) otitis media (OM) increases the risk of sensorineural hearing loss (SNHL) with semicircular canal transection in the guinea pig model.
METHODS: PA was injected transtympanically into both middle ears of pigmented guinea pigs. Saline-injected animals served as controls. Two to 4 days after injection, one horizontal semicircular canal was transected and sealed. Hearing was tested using electrocochleography before and after transection.
RESULTS: PA-OM was induced in all PA-injected ears. Five days after semicircular canal transection, click-evoked thresholds were significantly elevated in ears with PA-OM (P = 0.00009) but not in saline-injected ears (P = 0.398).
CONCLUSION: Violation of the inner ear in the presence of PA-OM is associated with increased risk of SNHL in the guinea pig.
SIGNIFICANCE: Factors unique to PA infection may be responsible for SNHL with labyrinthine injury in humans with chronic otitis media.
METHODS: PA was injected transtympanically into both middle ears of pigmented guinea pigs. Saline-injected animals served as controls. Two to 4 days after injection, one horizontal semicircular canal was transected and sealed. Hearing was tested using electrocochleography before and after transection.
RESULTS: PA-OM was induced in all PA-injected ears. Five days after semicircular canal transection, click-evoked thresholds were significantly elevated in ears with PA-OM (P = 0.00009) but not in saline-injected ears (P = 0.398).
CONCLUSION: Violation of the inner ear in the presence of PA-OM is associated with increased risk of SNHL in the guinea pig.
SIGNIFICANCE: Factors unique to PA infection may be responsible for SNHL with labyrinthine injury in humans with chronic otitis media.