Frontiers in allergy · 2026
Clinical characteristics and severity of concomitant atopic dermatitis in adults with asthma: a nationwide population-based registry study.
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Rønnstad Amalie Thorsti Møller, Ali Zarqa, Håkansson Kjell Erik Julius, Nielsen Mia-Louise, Nymand Lea Krog, Thomsen Simon Francis, Egeberg Alexander, Ulrik Charlotte Suppli, Thyssen Jacob P
Аннотация
BACKGROUND: Atopic dermatitis (AD) often coexists with asthma, but the characteristics of AD in adults with asthma are largely unknown.
OBJECTIVE: The objective of this work was to examine the characteristics and severity of AD in adults with asthma.
METHODS: This population-based registry study identified adults (18-45 years) with an inpatient or outpatient asthma diagnosis in Danish hospitals between 1 January 2000 and 31 December 2019. AD history was determined by inpatient or outpatient diagnostic codes. AD and asthma severity were assessed through patient surveys using the Patient-Oriented SCORing Atopic Dermatitis (PO-SCORAD) and the Global Initiative for Asthma (GINA) 2024.
RESULTS: Among 4,126 patients (15% response rate), 5.2% had AD. Of these, 22.7% were treated with GINA Step 4-5. Patients with AD were primarily women (74.3%) with childhood-onset AD (90.7%) and asthma (82.6%, p < 0.001). Mean (standard deviation) PO-SCORAD was 25.4 (16.1)). Asthma severity was not correlated or associated with AD severity. AD involvement in the head-and-neck region and on hands was common (54.0%; 61.3%) and associated with higher PO-SCORAD scores (p < 0.05; p < 0.001). AD flares during asthma exacerbations were reported by 33.0% of patients (p < 0.001).
CONCLUSIONS: Asthma patients with AD often have childhood onset of both conditions and mild-to-moderate AD. Clinicians should recognize that AD in high-burden skin areas is common in asthma patients.
OBJECTIVE: The objective of this work was to examine the characteristics and severity of AD in adults with asthma.
METHODS: This population-based registry study identified adults (18-45 years) with an inpatient or outpatient asthma diagnosis in Danish hospitals between 1 January 2000 and 31 December 2019. AD history was determined by inpatient or outpatient diagnostic codes. AD and asthma severity were assessed through patient surveys using the Patient-Oriented SCORing Atopic Dermatitis (PO-SCORAD) and the Global Initiative for Asthma (GINA) 2024.
RESULTS: Among 4,126 patients (15% response rate), 5.2% had AD. Of these, 22.7% were treated with GINA Step 4-5. Patients with AD were primarily women (74.3%) with childhood-onset AD (90.7%) and asthma (82.6%, p < 0.001). Mean (standard deviation) PO-SCORAD was 25.4 (16.1)). Asthma severity was not correlated or associated with AD severity. AD involvement in the head-and-neck region and on hands was common (54.0%; 61.3%) and associated with higher PO-SCORAD scores (p < 0.05; p < 0.001). AD flares during asthma exacerbations were reported by 33.0% of patients (p < 0.001).
CONCLUSIONS: Asthma patients with AD often have childhood onset of both conditions and mild-to-moderate AD. Clinicians should recognize that AD in high-burden skin areas is common in asthma patients.