Does sodium thiosulphate delay presbyacusis?

INTRODUCTION

This study compares the effects of sodium thiosulphate (STS) and normal saline on the prevention of hearing loss.

SETTING

Animal research laboratory.

METHODS

Sixteen mice were randomized to receive intraperitoneal injections of either normal saline or STS. Auditory brainstem response testing was used to determine baseline and posttreatment hearing thresholds over the course of 1 year.

RESULTS

Compared with saline, treatment with STS resulted in a statistically significant improvement in click and pure-tone thresholds until the end of the year.

CONCLUSION

STS can significantly delay hearing loss associated with age in this murine model.