American journal of human genetics · 2008
Genome-wide SNP-based linkage scan identifies a locus on 8q24 for an age-related hearing impairment trait.
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Huyghe Jeroen R, Van Laer Lut, Hendrickx Jan-Jaap, Fransen Erik, Demeester Kelly, Topsakal Vedat, Kunst Sylvia, Manninen Minna, Jensen Mona, Bonaconsa Amanda, Mazzoli Manuela, Baur Manuela, Hannula Samuli, Mäki-Torkko Elina, Espeso Angeles, Van Eyken Els, Flaquer Antonia, Becker Christian, Stephens Dafydd, Sorri Martti, Orzan Eva, Bille Michael, Parving Agnete, Pyykkö Ilmari, Cremers Cor W R J, Kremer Hannie, Van de Heyning Paul H, Wienker Thomas F, Nürnberg Peter, Pfister Markus, Van Camp Guy
Аннотация
Age-related hearing impairment (ARHI), or presbycusis, is a very common multifactorial disorder. Despite the knowledge that genetics play an important role in the etiology of human ARHI as revealed by heritability studies, to date, its precise genetic determinants remain elusive. Here we report the results of a cross-sectional family-based genetic study employing audiometric data. By using principal component analysis, we were able to reduce the dimensionality of this multivariate phenotype while capturing most of the variation and retaining biologically important features of the audiograms. We conducted a genome-wide association as well as a linkage scan with high-density SNP microarrays. Because of the presence of genetic population substructure, association testing was stratified after which evidence was combined by meta-analysis. No association signals reaching genome-wide significance were detected. Linkage analysis identified a linkage peak on 8q24.13-q24.22 for a trait correlated to audiogram shape. The signal reached genome-wide significance, as assessed by simulations. This finding represents the first locus for an ARHI trait.