medRxiv : the preprint server for health sciences · 2025
Risk and protective factors against cognitive decline in older adults from a nationally representative sample in India: Results from the LASI-DAD.
СтатьяПрепринтНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Gross Alden L, Nichols Emma, Rentería Miguel Arce, Khobragade Pranali Y, Meijer Erik, Ganguli Mary, Crimmins Eileen M, Dey Sharmistha, Dey Aparajit Ballav, Lee Jinkook, LASI-DAD Authorship Team
Аннотация
INTRODUCTION: We characterized modifiable risk and protective factors for cognitive decline in India.
METHODS: Using the first nationally representative population-based longitudinal sample of N=6,168 older adults in India, we evaluated associations of risk factors (demographic characteristics, self-reported and objective health characteristics, health behaviors, and sensory function) for late-life cognitive decline with up to 6.4 years of follow-up (range: 2.8 to 6.4 years).
RESULTS: The mean rate of general cognitive decline was -0.029 SD per year, and was progressively steeper with age. Most risk factors, particularly demographic and cardiovascular characteristics, were associated with steeper cognitive decline in expected directions: associations of history of high cholesterol or heart attack on rate of cognitive decline, for example, were comparable to being 11-12 years older.
DISCUSSION: Most risk factors were associated with change in expected directions, highlighting the potential generalizability to India of previously identified risk factors for dementia.
METHODS: Using the first nationally representative population-based longitudinal sample of N=6,168 older adults in India, we evaluated associations of risk factors (demographic characteristics, self-reported and objective health characteristics, health behaviors, and sensory function) for late-life cognitive decline with up to 6.4 years of follow-up (range: 2.8 to 6.4 years).
RESULTS: The mean rate of general cognitive decline was -0.029 SD per year, and was progressively steeper with age. Most risk factors, particularly demographic and cardiovascular characteristics, were associated with steeper cognitive decline in expected directions: associations of history of high cholesterol or heart attack on rate of cognitive decline, for example, were comparable to being 11-12 years older.
DISCUSSION: Most risk factors were associated with change in expected directions, highlighting the potential generalizability to India of previously identified risk factors for dementia.