Tau profiling across Alzheimer's disease staging reveals vulnerability to disease pathophysiology.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Bezgin Gleb, Pascoal Tharick A, Therriault Joseph, Lussier Firoza Z, Servaes Stijn, Kang Min Su, Savard Mélissa, Tissot Cécile, Stevenson Jenna, Wang Yi-Ting, Ottoy Julie, Rahmouni Nesrine, Fernandez-Arias Jaime, Hosseini Seyyed Ali, Aumont Étienne, Hall Brandon, Poltronetti Nina Margherita, Pallen Vanessa, Benedet Andréa Lessa, Ashton Nicholas J, Blennow Kaj, Zetterberg Henrik, Karikari Thomas K, Terada Tatsuhiro, Chamoun Mira, Mathotaarachchi Sulantha, Macedo Arthur Cassa, Stevenson Alyssa, Kunach Peter, Massarweh Gassan, Vitali Paolo, Soucy Jean-Paul, Iturria-Medina Yasser, Gauthier Serge, Rosa-Neto Pedro
Аннотация
METHODS: To address this gap, we propose the Manifold Component Analysis (MCA), for identifying pseudo-continuous profiles informed by the spatial continuity of stage regions.
RESULTS: Longitudinal and cross-sectional MCA in large aging cohort identified individual profiles (N = 753) expressing tau load in the entorhinal, limbic and neocortical regions. Using these profiles, we found neuropsychological and blood-based milestones of early and late disease stages. Finally, we also found evidence of rapid tau load increases and cognitive decline centered at the early-to-mid neocortical stages of Alzheimer's disease.
CONCLUSIONS: Stage system based on tau load and spreading profiles across cortical areas provide a compelling framework for inferring pathophysiological prognosis in Alzheimer's disease.