Dissociable spatial topography of cortical atrophy in early-onset and late-onset Alzheimer's disease: A head-to-head comparison of the LEADS and ADNI cohorts.
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Katsumi Yuta, Touroutoglou Alexandra, Brickhouse Michael, Eloyan Ani, Eckbo Ryan, Zaitsev Alexander, La Joie Renaud, Lagarde Julien, Schonhaut Daniel, Thangarajah Maryanne, Taurone Alexander, Vemuri Prashanthi, Jack Clifford R, Dage Jeffrey L, Nudelman Kelly N H, Foroud Tatiana, Hammers Dustin B, Ghetti Bernardino, Murray Melissa E, Newell Kathy L, Polsinelli Angelina J, Aisen Paul, Reman Rema, Beckett Laurel, Kramer Joel H, Atri Alireza, Day Gregory S, Duara Ranjan, Graff-Radford Neill R, Grant Ian M, Honig Lawrence S, Johnson Erik C B, Jones David T, Masdeu Joseph C, Mendez Mario F, Musiek Erik, Onyike Chiadi U, Riddle Meghan, Rogalski Emily, Salloway Stephen, Sha Sharon, Turner R Scott, Wingo Thomas S, Wolk David A, Womack Kyle, Carrillo Maria C, Rabinovici Gil D, Apostolova Liana G, Dickerson Bradford C, LEADS Consortium for the Alzheimer's Disease Neuroimaging Initiative
Аннотация
METHODS: We analyzed brain structural magnetic resonance imaging (MRI) data acquired from 377 sporadic EOAD patients and 317 sporadicLOAD patients who were amyloid positive and had mild cognitive impairment (MCI) or mild dementia (i.e., early-stage AD), along with cognitively unimpaired participants.
RESULTS: After controlling for the level of cognitive impairment, we found a double dissociation between AD clinical phenotype and localization/magnitude of atrophy, characterized by predominant neocortical involvement in EOAD and more focal anterior medial temporal involvement in LOAD.
DISCUSSION: Our findings point to the clinical utility of MRI-based biomarkers of atrophy in differentiating between EOAD and LOAD, which may be useful for diagnosis, prognostication, and treatment.
HIGHLIGHTS: Early-onset Alzheimer's disease (EOAD) and late-onset AD (LOAD) patients showed distinct and overlapping cortical atrophy patterns. EOAD patients showed prominent atrophy in widespread neocortical regions. LOAD patients showed prominent atrophy in the anterior medial temporal lobe. Regional atrophy was correlated with the severity of global cognitive impairment. Results were comparable when the sample was stratified for mild cognitive impairment (MCI) and dementia.