Successful treatment of rosacea by trephination combined with photodynamic therapy: A case report.

Rosacea is a chronic, inflammatory dermatological condition primarily affecting the central face, including the cheeks, nose, chin, and forehead [1]. It presents with erythema, phymatous changes, papules, pustules, and telangiectasia. The pathogenesis of rosacea is still unknown. Patients often suffer from multiple symptoms of rosacea, requiring more precise assessments and individualized therapies [2]. 5-Aminolevulinic acid photodynamic therapy (ALA-PDT) has shown promise as a safe and effective treatment for rosacea [3], especially in patients with multiple subtypes. We report a successful treatment involving a 46-year-old male patient with erythematotelangiectatic rosacea and phymatous changes using trephination combined with photodynamic therapy (PDT), improving quality of life without recurrence during the 9-month follow-up period.