Clinical problems in measles case management.

Measles remains one of the leading causes of childhood morbidity and mortality in developing countries. The World Health Organization has identified effective case management as one of the specific strategies to reduce the burden of this disease. The purpose of this article is to review the aetiology, natural history, treatment and outcome of the common clinical problems associated with measles with a view to identifying possible deficiencies in case management. Complications such as pneumonia, diarrhoea, croup and malnutrition have been well defined in terms of their relative contribution to morbidity and mortality. However, there are few published data on the aetiology and natural history of these specific complications. Such data are crucial for rational case management strategies. Data on treatment of measles and its complications are limited and the role of antibiotic prophylaxis and therapy is unclear. The only specific research focus on case management during the last decade has been vitamin A therapy. There is a continuing need for community and hospital-based studies on the natural history of measles and its complications, the aetiology of these complications and intervention strategies that will improve measles case management.