The effect of adjuvant treatment in obsessive compulsive disorder patients: A systematic review and meta-analysis.

INTRODUCTION

Obsessive-compulsive disorder (OCD) is a neuropsychiatric condition characterized by the presence of intrusive thoughts, referred to as obsessions, and repetitive behaviors, known as compulsions. Globally, OCD affects approximately 2-3% of the population.

MATERIALS AND

METHODS

Three databases (PubMed, Web of Science, and MEDLINE) were explored for the present study, from January 1, 2000 to December 31, 2024. The analysis was conducted using R version 4.3.2 to estimate the overall treatment effect of memantine and risperidone for OCD, relative to placebo, via meta-analysis. The Pooled Standardized Mean Differences (SMDs) were computed using both fixed-effect and random-effects models.

RESULTS

Only 10 studies were included in current investigation, after identification of 2362 articles. Meta-analysis of memantine suggested statistically insignificant (P value = 0.06) reduction in Y-BOCS score [SMD: -1.02 (-2.12, 0.08)], whereas meta-analysis of risperidone suggested statistically significant (P value = 0.03) reduction in Y-BOCS score [SMD: -0.38 (-0.74, -0.02)].

CONCLUSION

Risperidone plays a significant role in reduction of Y-BOCS score in OCD patients, whereas memantine does not show a significant effect in reducing the Y-BOCS score in OCD patients.