Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2015
Systematic Review of Treatments for Autoimmune Inner Ear Disease.
СтатьяСистематический обзорНазвание и аннотация: Перевод пока не подготовлен
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Brant Jason A, Eliades Steven J, Ruckenstein Michael J
Аннотация
OBJECTIVE: To systematically evaluate the evidence for treatment of autoimmune inner ear disease (AIED).
DATA SOURCES: Medline/EMBASE, Cochrane Review.
STUDY SELECTION: Studies reviewed were English language original articles reporting outcome data for subjects with AIED undergoing any treatment other than oral steroids alone with particular emphasis on prospectively collected data.
DATA EXTRACTION: The full text of articles meeting selection criteria was reviewed for subject inclusion criteria, number of subjects, treatment type and duration, audiologic and vestibular evaluations, blinding, randomization, and follow-up.
DATA SYNTHESIS: Twelve studies representing 272 subjects met selection criteria and presented prospective data, three of which were randomized and placebo controlled. Low numbers and heterogeneity between studies precluded meta analysis.
CONCLUSIONS: Clear evidence of an effective treatment for AIED from high-quality prospective trials remains lacking.
DATA SOURCES: Medline/EMBASE, Cochrane Review.
STUDY SELECTION: Studies reviewed were English language original articles reporting outcome data for subjects with AIED undergoing any treatment other than oral steroids alone with particular emphasis on prospectively collected data.
DATA EXTRACTION: The full text of articles meeting selection criteria was reviewed for subject inclusion criteria, number of subjects, treatment type and duration, audiologic and vestibular evaluations, blinding, randomization, and follow-up.
DATA SYNTHESIS: Twelve studies representing 272 subjects met selection criteria and presented prospective data, three of which were randomized and placebo controlled. Low numbers and heterogeneity between studies precluded meta analysis.
CONCLUSIONS: Clear evidence of an effective treatment for AIED from high-quality prospective trials remains lacking.