Schmerz (Berlin, Germany) · 2026
[Migraine in men: biological, psychosocial and clinical characteristics].
Аннотация на английскомСтатьяОбзорНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Hoehne Carolin Luisa, Andersen Wiebke, Raffaelli Bianca
Аннотация
BACKGROUND: Migraine affects 15% of the global population, with men being 2-3 times less frequently affected than women and are markedly underrepresented in research and clinical care. The condition is frequently underdiagnosed in men.
OBJECTIVE: The aim of this work is to describe the biological and psychosocial characteristics of migraine in men in order to improve the understanding of sex-related differences and to enhance the diagnostic precision and treatment for men.
MATERIAL AND METHODS: This article is a narrative review based on a structured literature search in PubMed using relevant search terms related to migraine and sex differences.
RESULTS: Biologically, men differ from women through hormonal influences on the calcitonin gene-related peptide (CGRP), pituitary adenylate cyclase-activating polypeptide (PACAP) and transient receptor potential (TRP) signaling pathways, which modulate pain processing. Clinically, men exhibit on average shorter attacks, lower intensity, more frequently dull-pressing pain and fewer vegetative accompanying symptoms. This presentation often leads to misdiagnosis. Additionally, role expectations, stigma and lower help-seeking behavior contribute to symptoms being reported later and underestimated more often. Although modern therapies are similarly effective in both sexes, men receive prophylactic treatment less frequently.
CONCLUSION: The sex-specific biological and psychosocial differences demonstrate that men present with a distinct clinical phenotype of migraine. Greater awareness with respect to these characteristics could enhance the diagnostic accuracy and support more individualized treatment.
OBJECTIVE: The aim of this work is to describe the biological and psychosocial characteristics of migraine in men in order to improve the understanding of sex-related differences and to enhance the diagnostic precision and treatment for men.
MATERIAL AND METHODS: This article is a narrative review based on a structured literature search in PubMed using relevant search terms related to migraine and sex differences.
RESULTS: Biologically, men differ from women through hormonal influences on the calcitonin gene-related peptide (CGRP), pituitary adenylate cyclase-activating polypeptide (PACAP) and transient receptor potential (TRP) signaling pathways, which modulate pain processing. Clinically, men exhibit on average shorter attacks, lower intensity, more frequently dull-pressing pain and fewer vegetative accompanying symptoms. This presentation often leads to misdiagnosis. Additionally, role expectations, stigma and lower help-seeking behavior contribute to symptoms being reported later and underestimated more often. Although modern therapies are similarly effective in both sexes, men receive prophylactic treatment less frequently.
CONCLUSION: The sex-specific biological and psychosocial differences demonstrate that men present with a distinct clinical phenotype of migraine. Greater awareness with respect to these characteristics could enhance the diagnostic accuracy and support more individualized treatment.