Nigerian journal of clinical practice · 2025
The Role of Serum Calprotectin in the Diagnosis of Acute Appendicitis.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Aydin I, Gulacti U, Turgut K, Yavuz E, Kara E
Аннотация
OBJECTIVE: This study aimed to evaluate the diagnostic accuracy of serum calprotectin as a potential biomarker in patients with acute appendicitis and to assess its correlation with clinical and laboratory parameters.
METHODS: A prospective case-control study was conducted over a 1-year period, including 60 consecutive emergency department patients with confirmed acute appendicitis and 30 healthy volunteers. Serum calprotectin levels were measured and compared in both groups. The relationship between calprotectin levels and Alvarado scores, appendix diameter (measured by imaging), and white blood cell (WBC) counts was analyzed using the Pearson correlation test.
RESULTS: The mean serum calprotectin level was significantly elevated in patients with acute appendicitis compared to healthy controls (626.2 ± 74.8 pg/mL vs. 40.6 ± 8.0 pg/mL, P < 0.001). No significant correlation was observed between serum calprotectin levels and Alvarado scores (r = -0.202, P = 0.122), appendiceal diameter (r = -0.182, P = 0.164), or WBC count (r = 0.033, P = 0.803). Receiver operating characteristic curve analysis revealed that serum calprotectin had a high diagnostic performance, with a cutoff value of 41.85 pg/mL yielding 95% sensitivity and 99.96% specificity (AUC: 0.957).
CONCLUSION: Serum calprotectin demonstrates high diagnostic accuracy in differentiating acute appendicitis from healthy controls, suggesting its potential utility as a novel biomarker in clinical practice. Further large-scale studies are warranted to validate its role in distinguishing complicated versus uncomplicated cases and its integration into diagnostic algorithms.
METHODS: A prospective case-control study was conducted over a 1-year period, including 60 consecutive emergency department patients with confirmed acute appendicitis and 30 healthy volunteers. Serum calprotectin levels were measured and compared in both groups. The relationship between calprotectin levels and Alvarado scores, appendix diameter (measured by imaging), and white blood cell (WBC) counts was analyzed using the Pearson correlation test.
RESULTS: The mean serum calprotectin level was significantly elevated in patients with acute appendicitis compared to healthy controls (626.2 ± 74.8 pg/mL vs. 40.6 ± 8.0 pg/mL, P < 0.001). No significant correlation was observed between serum calprotectin levels and Alvarado scores (r = -0.202, P = 0.122), appendiceal diameter (r = -0.182, P = 0.164), or WBC count (r = 0.033, P = 0.803). Receiver operating characteristic curve analysis revealed that serum calprotectin had a high diagnostic performance, with a cutoff value of 41.85 pg/mL yielding 95% sensitivity and 99.96% specificity (AUC: 0.957).
CONCLUSION: Serum calprotectin demonstrates high diagnostic accuracy in differentiating acute appendicitis from healthy controls, suggesting its potential utility as a novel biomarker in clinical practice. Further large-scale studies are warranted to validate its role in distinguishing complicated versus uncomplicated cases and its integration into diagnostic algorithms.