Journal of pharmacy & bioallied sciences · 2024
The Impact of Periodontal Therapy on Systemic Inflammatory Markers and Cardiovascular Disease Risk in Patients with Chronic Periodontitis.
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Shrivastava Deepti, Alanazi Abdullah R F, Altimani Zayed M A, Alsalem Abdullah M, Alam Mohammad K, Srivastava Kumar C
Аннотация
BACKGROUND: A common inflammatory condition that damages the tissues that support teeth, chronic periodontitis has become more closely associated with systemic health conditions, especially cardiovascular disease (CVD).
MATERIALS AND METHODS: In this randomized controlled experiment, 100 individuals with a diagnosis of chronic periodontitis were included. Two groups of participants were created: a treatment group (n = 50) that received scaling and root planning as well as other non-surgical periodontal care, and a control group (n = 50) that did not receive any treatment. Measurements were taken at baseline and 6 months after therapy for systemic inflammatory markers, including as C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α). The Framingham Risk Score (FRS) was used at the same intervals to evaluate the risk of CVD.
RESULTS: At 6 months after therapy, patients in the treatment group had substantial reductions in all measured inflammatory markers: CRP was down 30% (P < 0.01), IL-6 was down 25% (P < 0.05), and TNF-α was down 28% (P < 0.01). In the therapy group, the Framingham Risk Score dropped by 15% (P < 0.05), suggesting a lower chance of cardiovascular disease. There were no noteworthy alterations noted in the group under control.
CONCLUSION: In individuals with persistent periodontitis, non-surgical periodontal treatment may minimize the risk of cardiovascular disease and considerably reduce systemic inflammatory indicators.
MATERIALS AND METHODS: In this randomized controlled experiment, 100 individuals with a diagnosis of chronic periodontitis were included. Two groups of participants were created: a treatment group (n = 50) that received scaling and root planning as well as other non-surgical periodontal care, and a control group (n = 50) that did not receive any treatment. Measurements were taken at baseline and 6 months after therapy for systemic inflammatory markers, including as C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α). The Framingham Risk Score (FRS) was used at the same intervals to evaluate the risk of CVD.
RESULTS: At 6 months after therapy, patients in the treatment group had substantial reductions in all measured inflammatory markers: CRP was down 30% (P < 0.01), IL-6 was down 25% (P < 0.05), and TNF-α was down 28% (P < 0.01). In the therapy group, the Framingham Risk Score dropped by 15% (P < 0.05), suggesting a lower chance of cardiovascular disease. There were no noteworthy alterations noted in the group under control.
CONCLUSION: In individuals with persistent periodontitis, non-surgical periodontal treatment may minimize the risk of cardiovascular disease and considerably reduce systemic inflammatory indicators.